My current research is focusing on the liver cancer, particularly hepatocellular carcinoma under the metabolic dysfunction conditions. I did an animal model of over expression of lipogenic genes precede tumor development by altering of microenvironment in the liver tissue, especially macrophage M2 polarization due to CD8+ T cell exhaustion at the development of initial stage of HCC.
Another research theme is autophagy related gene deletion specific in the liver tissue and hepatocyte condition provoke early time point of cachexia mimic condition and severe HCC progression, which are very novel findings.
Through the above researches, first I I may get a clue how immune cells work under the metabolic dysfunctions and consider the therapeutic ways of immunotherapeutic to care initial stage of HCC. Moreover my second research will serve to me deep understanding for caring of cancer patients status such as cachexia as well as figuring out the hepatic immune cell networking during HCC development.
Post-doctoral Fellowship - Indiana University, Indianapolis, IN 2021
Ph.D. - Daejeon University, Daejeon 2015
