I serve as a research assistant professor at Indiana University, specializing in a distinctive combination of
bioinformatics and translational research in biomedical science. Collaborating with Dr. Xiongbin Lu, I apply
these skills to advance tumor immunology and cancer immunotherapy research. My overarching aim is to
establish myself as an independent researcher, focusing on cancer immunotherapy. Over the years, my
research has become uniquely positioned at the intersection of bioinformatics, hypoxia-associated
diseases, and cancer biology. This specialized skill set demands a profound understanding of handling
large-scale genomics data and implementing results for translational studies, including unraveling cancer
progression, and contributing to drug development. My ongoing research project involves creating in vivo
mouse models and ex vivo patient-derived organoid models to identify therapeutic targets impacting the
effectiveness of immune checkpoint blockade. This project introduces an innovative non-invasive
approach for developing microsatellite stable (MSS) and microsatellite instable (MSI) colon cancer mouse
models, replacing conventional cecal-wall injection methods and significantly enhancing success rates
while minimizing discomfort for experimental animals. Concurrently, I collaborate with fellow research
scientists to establish T cell-engaging tumor organoid models and explore cancer cell metabolism. This
collaboration accelerates multiple cancer immunotherapy projects in our laboratory, with current plans for
translation to clinical trials.
Post-doctoral Fellowship - Indiana University School of Medicine, Indianapolis, IN 2018-2023
