1. Advance the diagnostic tools used at the onset and follow-up of hematologic malignancies.
Specific goals of the K23 Mentored Patient-Oriented Research Career Development Award Project: Proteomic and computational methods in pediatric acute lymphoblastic leukemia.
1. Establish protein profiles of leukemic blasts from individual patients with childhood acute lymphoblatic leukemia and determine protein patterns specific for selected biological subgroups of this disease.
2. Determine protein profiles of sorted B-cell precursors from children without primary bone marrow disorders and adult healthy volunteer bone marrow donors, and compare obtained protein patterns to those of leukemia B-cells.
3. Intergrate protein profiles of individual patients with acute lymphoblastic leukemia into biospecimen database and using information visualization tools analyze the relationships between biologic, clinical, and proteomic data.
M.D. - Karol Marcinkowski University of Medical Sciences, Poznan, Poland 1990
Ph.D. - Karolinska Institute, Stockholm, Sweden
