Among all U.S. racial and ethnic categories, elevated body mass index is a leading cause of preventable death, a major risk factor for cardiovascular disease and several cancers. African American women with obesity have higher risk for cardiovascular disease and Type 2 diabetes compared to white people in the United States.
In the body, obesity-driven Type 2 diabetes creates inflammation that can lead to cardiovascular disease and cancers, such as breast cancer in postmenopausal women and colon cancer. In African American women, this risk is higher than for white women but not well understood.
For this study, researchers focused on subjects’ metabolic health, or all of the chemical processes in the body, to understand the effects of “cytokines,” small proteins that work with the immune system to control the growth of inflammation.
Inflammatory Signatures Distinguish Metabolic Health in African American Women with Obesity
What did they study?
Researchers analyzed 64 circulating cytokines and chemokines in plasma of 120 African American women enrolled in the Black Women's Health Study and 39 donors from the Komen Tissue Bank.
They looked at cytokines and other chemicals associated with obesity, Type 2 diabetes, and hypertension. They compared these results to those of obese women without those diseases as well as to lean women without those diseases.
What did they find?
The study generated six inflammation “signatures” of 16 different cytokines to identify similarities and differences, and to assign each sample an inflammation score. These signatures differed significantly in women who had obesity, with or without Type 2 diabetes.
Why is this study important?
This study suggests that body mass index alone is not a good enough measure of disease risks for African American women with obesity. Instead, this study suggests using a blood profile to assess inflammatory cytokines and metabolism to determine risk for disease.
Prevention and treatment tools would also be more personalized based on this kind of assessment.
Full citation
Denis GV, Sebastiani P, Bertrand KA, Strissel KJ, Tran AH, Slama J, Medina ND, Andrieu G, Palmer JR. Inflammatory signatures distinguish metabolic health in African American women with obesity. PLoS One. 2018 May 8;13(5):e0196755. doi: 10.1371/journal.pone.0196755. PMID: 29738558; PMCID: PMC5940209.
