Research innovations from HHM investigators
Members of the Hematopoiesis and Hematologic Malignancies research program at IU Simon Comprehensive Cancer Center are leading remarkable laboratory and clinical studies that reduce the burden of cancer.
Maura F, et al. Chromothripsis as a pathogenic driver of multiple myeloma. Semin Cell Dev Biol. 2022 Mar;123:115-123.
Naidu SR, et al. Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects. Leukemia. 2022 Mar;36(3):821-833. doi: 10.1038/s41375-021-01426-8. Epub 2021 Oct 1. PMID: 34599272.
Bickett TE, et al. Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Mol Ther. 2022 Mar 2;30(3):1149-1162.
63rd American Society of Hematology (ASH) Annual Meeting (December 2021):
- Obesity-Induced Inflammation Co-Operates with Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutants to Promote Leukemia Development and Cardiovascular Disease
- Mapping the High-Risk Multiple Myeloma Cell Surface Proteome Identifies T-Cell Inhibitory Receptors for Immune Targeting
- Extracellular DEK Treatment Mimics Hypoxic Blockade of Extra Physiologic Oxygen Stress in Human and Mouse Hematopoietic Cells
- A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma
Faculty Highlight: Ngoc Tung Tran, PhD
Ngoc Tung Tran, PhD, and colleagues published an article in the high-impact journal Science Advances for their work on gene editing in hematopoietic stem cells.
A faculty member of the Department of Pediatrics at IU School of Medicine, Dr. Tran is developing a research program to study hematopoietic malignancies. His ultimate goal is to develop gene therapy and therapeutic approaches for blood disorders.
