KEY Inclusion Criteria:
1. Previously untreated participants for lymphoma with documented cluster of
differentiation 20+ (CD20+) DLBCL, as described in the protocol OR relapsed or
refractory DLBCL (Part 1A only)
2. Measurable disease with at least one nodal lesion or at least one extranodal lesion,
as described in the protocol
3. Eastern Cooperative Oncology Group (ECOG) performance status ≤2
4. Life expectancy ≥ 12 months
5. International Prognostic Index (IPI) of 3 to 5 (part 1 only) and ≥2 (part 2) for
untreated DLBCL only;
6. Adequate hematologic and organ function, as defined in the protocol.
KEY Exclusion Criteria:
1. Primary central nervous system (CNS) lymphoma or known involvement by non-primary CNS
NHL and history or current relevant CNS pathology
2. Another active malignancy, significant active disease or medical condition, as
described in the protocol
3. Peripheral neuropathy Grade ≥3
4. Treatment with any systemic anti-lymphoma therapy
5. Any investigational therapy within 28 days or 5 half-lives of the drug, whichever is
shorter, prior to the start of study treatment
6. Recent major surgery, prior organ transplantation, or standard radiotherapy, as
described in the protocol
7. Allergy/hypersensitivity to study drugs, as described in the protocol
8. Infections such as any active infection (bacterial, viral, fungal, mycobacterial,
parasitic or other), active Coronavirus disease (COVID-19) infection, uncontrolled
infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV), or
hepatitis C virus (HCV), Cytomegalovirus (CMV) infection, as described in the
protocol.
Note: Other protocol-defined Inclusion/ Exclusion criteria apply