Subjects age 18 years and older who are at an increased risk for HCC and for whom HCC
surveillance is appropriate, including subjects with cirrhosis or non-cirrhotic subjects with
Hepatitis B. Approximately 3,000 subjects are expected to be enrolled, comprised of
approximately 2,222 ultrasound surveillance subjects and 778 subjects under surveillance with
1. Be 18 years of age or older.
2. Understand the study procedures, be able to provide written informed consent to
participate in the study, and have authorization for release of data, including
personal health data and images, to the study Investigator, Sponsor, and regulatory
3. Present for surveillance imaging due to increased risk for HCC, including either:
1. Diagnosis of cirrhosis based on at least one of the following:
- Histology from a liver biopsy.
- Ultrasound, CT, or MRI showing a cirrhotic liver combined with portal
hypertension (as evidenced by the presence of intra-abdominal varices, or
recanalized umbilical vein, or ascites or splenomegaly or thrombocytopenia
[defined as Platelet count < 150,000]). The imaging results must have been
obtained within 5 years of study enrollment.
- Liver stiffness â¥4.71 kilopascal (kPa) by Magnetic Resonance (MR)
elastography or â¥12.1 kPa by vibration controlled transient elastography.
- Presence of varices on endoscopy or imaging and presence of a chronic liver
2. Non-cirrhotic subjects with chronic Hepatitis B Virus (HBV) infection (Hepatitis
B surface antigen present for >6 months)
1. Known cancer diagnosis (including active malignancy) within the past 5 years except
for nonmelanoma skin cancer.
2. Chemotherapy and/or radiation therapy within 5 years prior to study enrollment.
3. Child-Pugh class C liver function at the time of enrollment, except for those on the
waiting list for transplant.
4. Solid liver nodule >1 cm by ultrasound or elevated Alpha-fetoprotein (AFP) (>100
ng/mL) in 12 months preceding the qualifying surveillance imaging visit without
subsequent documentation of HCC negative or LIRADS 1 (Liver Imaging Reporting and Data
System) by diagnostic CT/MRI.
5. Females known to be pregnant at the time of enrollment.
6. Illness that the Investigator believes poses a significant risk of mortality during
the study period, including but not limited to
1. Congestive heart failure with ejection fraction <50%
2. Chronic lung disease requiring supplemental oxygen.
3. History of recent stroke.
7. Sustained virologic response (SVR) for Hepatitis C Virus (HCV) (undetectable HCV RNA
12 to 24 weeks after completion of antiviral therapy) for >10 years prior to
8. Not able to have IV contrast for CT or MRI due to
1. Allergy to IV contrast and unwilling or unable to receive IV contrast after
2. Estimated glomerular filtration rate <35 mL/min and not on hemodialysis.