2023 American Society of Hematology Annual Meeting

Indiana University Melvin and Bren Simon Comprehensive Cancer Center researchers shared their findings at the 2023  American Society of Hematology (ASH) Annual Meeting. The world’s largest hematology event, ASH brings together more than 20,000 hematology professionals. This year’s event was Dec. 9-12 in San Diego.

IU researchers shared findings on multiple myeloma, juvenile myelomonocytic leukemia (JMML), acute myeloid leukemia (AML), among other topics.

Cancer center highlights include:

• Unraveling Diverse Mechanisms of Complex Structural Variant Interactions through Multiomic Data in Multiple Myeloma
  Brian A. Walker, PhD, shared these findings during an oral presentation. Additional cancer center authors: Enze Liu, PhD,  Attaya Suvannasankha, MD, Kelvin P. Lee, MD, and Rafat Abonour, MD.
  
  
• Neuropeptide Y Attenuates Aging-Induced Bone Marrow Niche Defects and Rejuvenate Aged Hematopoietic Stem/Progenitor Cells
  Dinisha Kamble, PhD, a postdoctoral fellow conducting research in the lab of Pratibha Singh, PhD, presented the findings during an oral presentation. Additional IU authors: Nick Imperiale and Pratibha Singh, PhD.
  
  
• Maternal Obesity Causes Sex Specific Long-Term Hematopoietic and Metabolic Defects
  Maegan L Capitano, PhD, shared these findings during an oral presentation. Additional cancer center authors: James Ropa, PhD.
  
  
• Targeting Loss of the Tumor Suppressor TENT5C in Multiple Myeloma Oumaima
  Jaouadi, PhD, a postdoctoral fellow, presented the findings during a poster session. Additional cancer center authors: Enze Liu, PhD, and Brian A. Walker, PhD.
  
  
• Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: A Report from the Children’s Oncology Group
  Steven Angus, PhD, and Steven Rhodes, MD, PhD, are among the authors of this oral presentation.
  
  
• Untangling Amyloidosis 2023: Diagnosis, Prognosis, Selection of Individualized Therapy, and Management of Difficult Clinical Complications
  Rafat Abonour, MD, was a speaker for this CME symposium that preceded the meeting. 

Additional cancer center members and IU School of Medicine researchers with findings at this year’s ASH include Larry D. Cripe, MD; Magdalena Czader, MD, PhD; Uptal P. Davé, MD; Alexander Dent, PhD; Seethal A. Jacob, MD; Mark H Kaplan, PhD; Kelvin P. Lee, MD; Yunlong Liu, PhD; Reynold Ly, PhD; Andrew O’Brien, MD; Michael J. Robertson, MD; Pratibha Singh, PhD; Kirk A. Staschke, PhD; Attaya Suvannasankha, MD; Ngoc Tung Tran, PhD; and Chi Zhang, PhD.