Member Biography

Keith March

Keith March, M.D., Ph.D.

975 W. Walnut St.
IB 441
Indianapolis, IN 46202
Phone: (317) 988-4976

Research Program Membership

Full member

Cryptic Masons Medical Research Foundation Professor of Vascular Biology Research
IU School of Medicine

Professor of Medicine
Department of Medicine
Division of Cardiology
IU School of Medicine

Department of Cellular and Integrative Physiology

Professor, Biomedical Engineering
Purdue University

We wish to extend our prior studies of adipose stromal cells to evaluate their therapeutic potential in the context of their known tropism to several tumor tissues. This tumor-homing behavior was first explored by our group, working in collaboration with Dr. Mikhail Kolonin, and our findings were published last year in Cancer Research. Our laboratory has been one of the leaders in the field of those developing an understanding of the pluripotent cells in adipose tissue, and the concept that adipose tissue provides a novel, readily-available autologous source of cells with significant potential for tissue modification. We will extend this concept to study the activity of ASC as a readily available cellular vector which can carry therapeutic tumor-targeted genes to the sites of tumors and their vasculature. Work from our laboratory and Center has clearly demonstrated that ASCs can increase tissue perfusion and limit ischemic tissue damage in several circumstances, including models of acute skeletal muscle, myocardial, and cerebral ischemia, as well as in cutaneous wound healing, particularly when impaired by prior irradiation. Evidence derived from each of these models has consistently indicated that these effects are predominantly mediated by action of the ASC on the vasculature in the area of injury, via factors secreted by ASCs rather than differentiation to replace tissue parenchyma. We are now therefore interested to determine whether the natural homing behavior of AS

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Fellowship - Indiana University School of Medicine, Indianapolis, IN 1990

Residency - Indiana University School of Medicine, Indianapolis, IN 1988

M.D. - Indiana University School of Medicine, Indianapolis, IN 1985

Ph.D. - Indiana University, Bloomington, IN 1983