Member Biography

Jesse Gore, Ph.D.

980 W. Walnut St.
R3 C541
Indianapolis, IN 46202

Phone: (317) 278-6411

Research Program Membership

Assistant Research Professor
Department of Medicine
Division of Endocrinology
IU School of Medicine

My current research employs several approaches for preclinical modeling of pancreatic ductal adenocarcinoma (PDAC) to identify new genetic and molecular alterations that promote PDAC growth and metastasis, and to test novel therapies. These models include novel genetically engineered mouse models (GEMMs), and orthotopic models established using murine and human pancreatic cancer cells and human pancreatic cancer tissue biopsies. My research using such models has revealed the existence of direct mitogenic effects of TGF-beta on pancreatic cancer cells, and indirect effects within the tumor microenvironment all of which can be targeted by TGF-beta receptor kinase inhibition. I have also established mechanisms through which TGF-beta signaling pathways can promote angiogenesis in PDAC and foster deleterious cross-talk between endothelial cells and pancreatic cancer cells. My long-term research goals are to assess new pathways that regulate pancreatic cancer growth and metastasis in relation to the tumor microenvironment, and to test novel therapeutic approaches in clinically-relevant pre-clinical models to combat this deadly cancer.

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More Publications »

Post-doctoral Fellowship - Indiana University School of Medicine, Indianapolis, IN 2013

Post-doctoral Fellowship - Dartmouth College, Hanover, NH 2011

Ph.D. - North Carolina University, Chapel Hill, NC 2008