Hematopoiesis & Hematologic Malignancies

Hematopoiesis LabThe goal of the Hematopoiesis and Hematologic Malignancies (HHM) research program is to enhance treatment of hematologic malignancies — with a focus on leukemia, pre-leukemia, and multiple myeloma — through rigorous basic mechanistic scientific laboratory efforts, including in vitro cell culture and in vivo pre-clinical animal studies using mouse and human cells.

The program has two themes:

Theme 1: Hematopoiesis (H)

  • Aim 1. Regulation of human and mouse hematopoietic stem (HSC) and progenitor (HPC) cells.
  • Aim 2. HSC and HPC engraftment, mobilization and transplantation.

Theme 2: Hematologic Malignancies (HM)

  • Aim 1. Signaling of hematologic malignancies ((i.e. leukemia, myeloma, lymphoma).
  • Aim 2. Hematologic malignancies and bone microenvironment.