Member Biography


Monte Willis

Monte Willis, MD PhD, MBA

635 Barnhill Drive
MS 5067F
Indianapolis, IN 46202
Phone: (317) 278-2674
Fax: (317) 278-6500

Research Program Membership

Full member:

Professor of Pathology & Laboratory Medicine
Department of Pathology and Laboratory Medicine
IU School of Medicine

Deputy Director, Indiana University Center for Musculoskeletal Health
IU School of Medicine

Dr. Willis's research interests include:

The two major themes of my research program include: 1) Studying the role of muscle-specific ubiquitin ligases (MuRF proteins) in cardiac and skeletal muscle atrophy (including cancer cachexia) and their role in cell signaling and metabolism; and 2) Identifying the role of muscle-specific ubiquitin ligases degrade inherited mutant muscle proteins (e.g., cMyBP-C and BAG3 proteins) in the pathogenesis of heart failure. We have extensive experience with pre-clinical studies of therapies using 1) peptide-inhibitor of MK2 (MMI-0100); 2) peptide-conjugated morpholino oligomers; 3) NEMO-binding domain (NBD) peptides; 4) two small molecule inhibitors of NF-¿B (I¿B); 5) proteasome inhibition; and 6) anti-MIF neutralizing antibodies in heart failure models of muscular dystrophy, cancer cachexia, cardiac atrophy, and myocardial infarction. Dr. Willis is the Deputy Director of the Indiana Center for Musculoskeletal Health, Vice-Chair of Research in the Department of Pathology & Laboratory Medicine and is a practicing clinician overseeing the clinical chemistry laboratory and the IU School of Medicine’s clinical metabolomics program. Dr. Willis has published extensively on the use of metabolomics (both targeted and non-targeted methodologies) for basic science, translational, and clinical applications, including 19 publications since 2015.

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M.B.A. - Kenan-Flagler Business School University of North Carolina at Chapel Hill 2012-2014

Residency - University of North Carolina at Chapel Hill, Chapel Hill, NC 2004-2005

Post-doctoral Fellowship - University of Texas Southwestern Medical Center, Dallas, TX 2002-2004

Residency - University of Texas Southwestern Medical Center, Dallas, TX 2001-2004

M.D. - University of Nebraska Medical Center, Omaha, NE 1993-2001

Ph.D. - University of Nebraska Medical Center, Omaha, NE 1993-2001