Dan Spandau, Ph.D.
975 W. Walnut St.
Indianapolis, IN 46202
Phone: (317) 274-7115
Research Program Membership
Dr. Spandau's research interests include:
Although skin cancer can occur at any age, there is a strong correlation between the development of skin cancer and advancing age. Recent in vitro, in vivo, and epidemiological data suggests that alterations in the insulin-like growth factor-1 receptor (IGF-1R) signaling network influence aging-associated photocarcinogenesis. Using normal human keratinocytes grown in vitro, activated IGF-1Rs protect keratinocytes from UVB-induced apoptosis; however, while UVB-irradiated keratinocytes with activated IGF-1Rs survive, they are incapable of further cellular replication, in fact they are senescent. The critically important observation was that in the absence of IGF-1R activation, keratinocytes are more sensitive to UVB-induced apoptosis, but the keratinocytes that do survive retain the capacity to proliferate. In the skin, dermal fibroblasts support the proliferation of keratinocytes in the epidermis by secreting IGF-1. Interestingly, as dermal fibroblasts age, their capacity to produce IGF-1 is severely diminished. We have demonstrated that geriatric skin responds to UVB irradiation in a manner that could lead to initiated carcinogenic keratinocytes. This inappropriate UVB response can be corrected by treatment with exogenous IGF-1. Furthermore, we have shown that treatment of geriatric skin with ablative dermal rejuvenation therapies can re-establish youthful IGF-1 levels and subsequently reinstate the appropriate UVB response on sun-protected skin.
Post-doctoral Fellowship - Indiana University, Indianapolis, IN 1990
Ph.D. - Indiana University, Indianapolis, IN 1987
M.S. - Indiana University, Indianapolis, IN 1986