Member Biography

Silvia Marino

Silvia Marino, PhD

980 W. Walnut Street
Indianapolis, IN 46202
Phone: (317) 278-7270

Research Program Membership

Associate member:

Assistant Research Professor
Department of Medicine
Division of Hematology/Oncology
IU School of Medicine

Dr. Marino's research interests include:

I am an Assistant Professor in the Division of Hematology/Oncology at Indiana University School of Medicine. For the past 7 years, the primary focus of my research has been to understand the crosstalk between cancer and bone cells. During the past several years, my scientific interests have focused on the identification of the cellular and molecular mechanism(s) responsible for multiple myeloma (MM) disease progression, and osteoblast suppression in MM. I am currently investigating SQSTM1/p62 as a druggable target for MM and cancer-associated bone disease. My preliminary findings indicate that a small molecule inhibitor of p62, developed by our research team, prevents MM-induced epigenetic changes in pre-osteoblasts, thereby restoring their ability to differentiate into bone forming cells. It also sensitizes MM cells to the cytotoxic effects of proteasome inhibitors used in MM therapies. Thus, targeting p62 as a modulator of tumor growth and osteoblast function may be valuable for developing therapeutics that decrease tumor burden, overcome drug resistance and heal osteolytic lesion in MM patients. My ultimate goal is to develop novel effective therapeutic agents for the prevention and treatment of MM-associated bone disease, which occurs in 90% of MM patients.

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More Publications »

Post-doctoral Fellowship - University of Sheffield, Sheffield, UK 12/2016

Pharm.D. - University of Turin, Turin, Italy 11/2007

Post-doctoral Fellowship - Indiana University School of Medicine, Indianapolis, IN 04/2018

PHMD - University of Turin/University of Edinburgh 02/2013