Biospecimen Collection & Banking Core

The Biospecimen Collection and Banking Core – or BC² – merges the IUSCCC Tissue Procurement Core, the Komen Tissue Bank, and the biobanking efforts of both the cancer center’s Clinical Trials Office and those done as a member of the Oncology Research Information Exchange Network (ORIEN).

The core supports cancer research by providing comprehensive biospecimen management, including:

  • Collection
  • Storage
  • Distribution
  • Annotation (in collaboration with others)

In addition, the following three work groups have been formed, with each headed by the following staff:

Komen Tissue Bank at IUSCCC

The Komen Tissue Bank at the IU Simon Cancer Center is the only normal breast tissue bio-repository of its kind in the world, making it uniquely positioned to characterize the molecular and genetic basis of normal breast development and compare it to the different types of breast cancer. It was established expressly for the acquisition of normal  tissues — breast tissue, cryopreserved tissue, serum, plasma and DNA — from volunteer donors with no clinical evidence of breast disease and/or malignancy, providing a resource to investigators around the globe. Visit for additional detailed information.

Tissue Procurement

The Tissue Procurement and Distibution Core collects fresh, frozen and formalin fixed paraffin-embedded malignant solid tumors as well as histologically normal adjacent tissue, whole blood, plasma, serum and cellular (MNC/DNA) components; bone marrow aspirate; urine, pleural and paracentesis fluid.

Operationally embedded within IU Health Pathology, the core supports immediate access to surgical and other clinical areas for sample collection within multiple facilities, including IU Health University Hospital, IU Simon Comprehensive Cancer Center, IU Health Riley Hospital, IU Health Methodist Hospital and Eskenazi Health.

Rapid processing is key to maintaining quality: The core receives all specimens within 90 minutes of excision, with greater than 70 percent within 30 minutes of excision. Clinical annotation associated with collected samples, including demographics, medical, family, and social history, medical treatment, pathological diagnosis and ancillary studies, is maintained in the secure Oncore® Biospecimen Management (BSM) database.

Additional data can be collected from consented patients should an approved project require. Since 2015, the core has assisted with tissue procurement, processing, storage and shipping of sample collections embedded in therapeutic and correlative solid tumor clinical trials. This trial-specific service has supported nine separate protocols.

The specific aims of the core are to:

Specific Aim 1: To provide well-annotated, diverse, high quality biologic material to support basic and translational solid tumor research.

Specific Aim 2: To coordinate procurement, processing, storage, and management of tissue samples collected in conjunction with therapeutic and correlative solid tumor clinical trials.

Specific Aim 3: To develop and maintain tissue microarrays to support biomarker research.

Specific Aim 4: To collaborate with investigators to provide analyses of banked, archived, or tissue microarray samples, including pathologic characterization and immunohistochemistry.


BC² merges the following:

IUSCCC Tissue Procurement Core supports immediate access to surgical and other clinical areas for sample collection within multiple facilities,

Komen Tissue Bank is the world's only healthy breast tissue bank.

IUSCCC Clinical Trials Office's biobanking efforts

Oncology Research Information Exchange Network (ORIEN) is an alliance of cancer centers, powered by M2GEN, working in close collaboration to accomplish more in the fight against cancer.