Member Biography

Yan Xu

Yan Xu, Ph.D.

975 W. Walnut St.
IB 355A
Indianapolis, IN 46202
Phone: (317) 274-3972
Fax: (317) 278-2884

Research Program Membership

Full member

Hulman-George Family Professor of Gynecologic Cancer
IU School of Medicine

Department of Obstetrics and Gynecology
IU School of Medicine

Department of Biochemistry and Molecular Biology
IU School of Medicine

My main interests deals with understanding, at the molecular lever, the mechanism of development of ovarian, breast, prostate, and other malignancies. These include developing effective diagnostic and prognostic biomarkers for these diseases and novel therapeutic targets and methods to treat them. We will continue to 1) investigate the role and signaling mechanisms of bioactive lipip molecules, lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), and sphingosylphosphorylcholine (SPC) and their receptors in cancer and other diseases; 2) determine the structure-function relationship of the OGR1-subfamily receptors and establish molecular models of these receptors for drug development; and 3) determine the physiological roles and functions of OGR1-subfamily receptors using mouse knockout models.

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Post-doctoral Fellowship - The Hospital for Sick Children, Toronto, Canada 1988-1991

Ph.D. - The State University of New York at Albany, NY 1988