Member Biography

Rebecca J. Chan

Rebecca Chan, M.D., Ph.D.

1044 W. Walnut St.
R4 W170
Indianapolis, IN 46202
Phone: (317) 278-2807

Research Program Membership

Full member

Associate Professor
Department of Pediatrics
IU School of Medicine

Associate Professor
Department of Medical and Molecular Genetics
IU School of Medicine

My laboratory is focused on the role of the protein tyrosine phosphatase, Shp2, in childhood and adult myeloid leukemia. Activating somatic mutations in the gene encoding Shp2, PTPN11, are found in 35% of children with juvenile myelomonocytic leukemia (JMML). Additionally, Shp2 expression is commonly upregulated in acute myeloid leukemia (AML) and Shp2 function likely works together with other oncogenes (such as activating FLT3-ITD or KITD816D mutants) to promote leukemogenesis. The long term goals of my research program are to utilize genetic methods to dissect the aberrantly regulated signaling pathways involving Shp2 in an effort to define novel therapeutic targets in myeloid leukemia. By better understanding how cytokine-stimulated signaling pathways and cell growth are dysregulated in the presence of mutant Shp2 or hyperactivation of Shp2, we hope to define new therapeutic targets for myeloid leukemias.

Importing from PubMed - Please Wait...

More Publications »

Post-doctoral Fellowship - Indiana University, School of Medicine, Indianapolis, IN 1999-2002

Fellowship - Indiana University, School of Medicine, Indianapolis, IN 1998-1999

Residency - UCLA School of Medicine, Los Angeles, CA 1995-1998

Ph.D. - Indiana University, Indianapolis, IN 1995

M.D. - Indiana University, School of Medicine, Indianapolis, IN 1995