Mark Green, Ph.D.
950 W. Walnut St.
Indianapolis, IN 46202
Phone: (317) 278-9844
Fax: (317) 274-1067
Research Program Membership
Professor of Radiology & Imaging Sciences
Department of Radiology and Imaging Services
IU School of Medicine
My research focuses on the design, synthesis, and evaluation of new radiopharmaceuticals. Experimentally, this research encompasses a broad spectrum of laboratory activities, beginning with the synthesis and characterization of novel chelating ligands and metal complexes using conventional laboratory techniques. Subsequently, the chemistry is scaled down to the minute sub-pharmacologic concentrations found in most radiopharmaceutical formulations. These new agents are then evaluated in animal models to directly determine radiotracer biodistribution, pharmacokinetics, and chemical fate in vivo. The resulting biological data are used in elucidation of structure-activity relationships, as well as providing a basis for assessing potential clinical utility. The best compounds identified in initial screening are subsequently examined in more sophisticated models that allow, under a variety of physiological conditions, direct evaluation of the relationship between tracer uptake and specific aspects of tissue physiology. For promising tracers identified in this manner, additional preclinical evaluations complete a foundation for translation to clinical assessment of radiopharmaceutical performance in humans. Current research efforts include development of tracers for the study of regional tissue perfusion (cerebral, myocardial, renal, and tumor blood flow), as well as investigation of general strategies for selective radiotracer targeting to neoplastic tissue.
Post-doctoral Fellowship - Washington University, St. Louis, MO 1982-1985
Ph.D. - Indiana University, Bloomington, IN 1982