Julie Otte, Ph.D., R.N.
1111 Middle Drive
Indianapolis, IN 46202
Phone: (317) 274-0886
Fax: (317) 278-1856
Research Program Membership
IU School of Nursing
Current research interests focus on a proposed research project (CTSI funded) to determine the relationship among sleep disturbances, hot flashes, and orexin levels in breast cancer survivors (BCS). Menopausal symptoms may cluster due to a common shared etiology related to the orexin neuronal system. Orexins are activating neuropeptide hormones (chemical messengers to the brain and body). Orexin A crosses the blood brain barrier with ease in mice and, in females, peripheral plasma concentrations appear to serve as valid indicators of orexin neuronal system functioning. Hypothalamic orexin A expression is inversely related to estrogen levels suggesting that higher orexin A concentrations are seen when estrogen is lower, such as during menopause. Orexin A may be implicated in single or clustered menopausal symptoms and no prior animal or human research has evaluated the relationship between orexins and menopause or menopausal symptoms in BCS. This important translational research will be the first of its kind to study the role of orexin in menopausal symptoms in BCS. Future research will continue to focus on translational research to further develop conceptual knowledge of sleep disturbances in BCS, delineate sleep disturbances in BCS through identifying additional physiological links between sleep disturbances, hot flashes, and mood disturbances through interdisciplinary collaborations with clinicians and research-scientist.
Post-doctoral Fellowship - Indiana University, Indianapolis, IN 2008-2009
Ph.D. - Indiana University, Indianapolis, IN 2004-2008
M.S.N. - Vanderbilt University, Nashville, TN 2000-2002
B.S.N. - Prudue University, W. Lafayette, IN 1991-1996