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Stieglitz E, Lee AG, Angus SP (EDT), Davis C, Barkauskas DA, Hall D, Kogan SC, Meyer J, Rhodes SD (CBM), Tasian SK, Xuei X, Shannon K, Loh ML, Fox E, Weigel BJ. Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: a Report from the Children's Oncology Group. Cancer Discov. 2024 SEP 04; 14(9):1590-1598. DOI: 10.1158/2159-8290.CD-23-1376. PubMed PMID: 38867349; PMCID: PMC11374478.
Xu J, Apetoh L (CBM). Go to the scene: TH9 cells superior migration ability to the lungs explains their exceptional anticancer efficacy. J Immunother Cancer. 2025 APR 28; 13(4). DOI: 10.1136/jitc-2025-011522. 2025 Apr 28. PubMed PMID: 40295144; PMCID: PMC12039026.
Barghi F (TT), Saadatzadeh MR, Dobrota EA, Shannon HE, Bailey BJ, Young C, Malko R, Justice R, Riyahi N (TT), Davis C, Bijangi-Vishehsaraei K, Kreklau K, Stevens LK, Koenig J, Sulayman S, Liu S, Wan J (UA), Trowbridge MA, Coy K, Kennedy FM, Sinn AL, Just M (EDT), Jackson KW (CBM), Sandusky G, Wurtz LD, Collier CD (CBM), Mitchell D, Seiden EE (TT), Greenfield EM (CBM), Doud E, Mosley A (EDT), Angus SP (EDT), Ferguson MJ, Pandya PH, Pollok KE (EDT). Dual CDK4/6-PI3K/mTOR inhibition reinforces cytostatic programs and tumor control in preclinical models of primary and metastatic osteosarcoma. Neoplasia. 2026 FEB 01; 72:101266. DOI: 10.1016/j.neo.2025.101266. 2026 Jan 15. PubMed PMID: 41544376; PMCID: PMC12830294.
Fu D, Jiang H, Long A, Harris E, Guo H, Capitano ML (CBM), Wrangle J, Faust JR, Gopalakrishnapillai A, Pasupuleti SK (CBM), Ramdas B, Kapur R (CBM), Barwe SP, Cheung NV, Paczesny S. Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway. Nat Commun. 2025 JUL 14; 16(1):6369. DOI: 10.1038/s41467-025-61567-7. 2025 Jul 14. PubMed PMID: 40659660; PMCID: PMC12259856.
Li C, Xie Q, Ghosh S, Cao B, Du Y, Vo GV, Huang TY, Spruck C, Carpenter RL (CBM), Wang YA (EDT), Lu QR, Nephew KP (CBM), Shen J (CBM). SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma. JCI Insight. 2025 MAR 10; 10(5). DOI: 10.1172/jci.insight.186344. 2025 Mar 10. PubMed PMID: 40059829; PMCID: PMC11949068.
Chowdhury NN (TT), Mitchell DK, Kangro K, Eldridge K, Abrahams S, Ferraresso F, Juang LJ, Gampala S, Brewster K, Revenko A, Kastrup C, Territo PR, Clapp DW (CBM), Wang J, Belgodere JA, Saeed O, Choi SR, Han B, Wolberg AS, Cao S, Zhang C, Flick MJ, Fishel ML (CBM). Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2025 DEC 23; . DOI: 10.1053/j.gastro.2025.09.024. 2025 Dec 23. PubMed PMID: 41432649; PMCID: PMC12731649.
Cordova RA (TT), Elbanna M (TT), Rupert C, Orsi SA, Sommers NR, Klunk AJ, Shen L, Misra J, Hanquier JN, Tsompana M, Wang Y, Goodrich DW, Wek RC (CBM), Fontana L, Staschke KA (EDT), Pili R. Caloric Restriction Enhances the Efficacy of Antiandrogen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation. Cancer Res. 2025 NOV 03; 85(21):4182-4197. DOI: 10.1158/0008-5472.CAN-24-1986. PubMed PMID: 40779415; PMCID: PMC12535181.
Zhang D, Schroeder A, Yan H, Yang H, Hu J, Lee MYY, Cho KS, Susztak K, Xu GX, Feldman MD (CBM), Lee EB, Furth EE, Wang L, Li M. Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology. Nat Biotechnol. 2024 SEP 01; 42(9):1372-1377. DOI: 10.1038/s41587-023-02019-9. 2024 Jan 2. PubMed PMID: 38168986; PMCID: PMC11260191.
Ladaika CA, Ghobashi AH (TT), Boulton WC, Miller SA (TT), O'Hagan HM (CBM). LSD1 and CoREST2 Potentiate STAT3 Activity to Promote Enteroendocrine Cell Differentiation in Mucinous Colorectal Cancer. Cancer Res. 2025 JAN 02; 85(1):52-68. DOI: 10.1158/0008-5472.CAN-24-0788. PubMed PMID: 39365378; PMCID: PMC11695186.
Karnik SJ, Gulbronson C, Jordan PC, Kanumuri R (TT), Ramdas B, Kumar R, Hartman ML, Khurram I, Brown DM, Pollok KE (EDT), Singh P (CBM), Kapur R (CBM), Kacena MA (CBM). Multiplex imaging of murine bone marrow using Phenocycler 2.0™. Leukemia. 2025 JUN 01; 39(6):1476-1489. DOI: 10.1038/s41375-025-02596-5. 2025 Apr 11. PubMed PMID: 40217069; PMCID: PMC12133563.
Khaliq AM (RT/CBM), Rajamohan M, Saeed O, Mansouri K, Adil A, Zhang C, Turk A (EDT), Carstens JL, House M, Hayat S, Nagaraju GP, Pappas SG, Wang YA (EDT), Zyromski NJ, Opyrchal M (EDT), Lee KP (HHM), O'Hagan H (CBM), El Rayes B, Masood A (EDT). Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity. Nat Genet. 2024 NOV 01; 56(11):2455-2465. DOI: 10.1038/s41588-024-01914-4. 2024 Sep 18. PubMed PMID: 39294496.
Bhat-Nakshatri P, Gao H, Khatpe AS (TT), Adebayo AK (TT), McGuire PC, Erdogan C, Chen D, Jiang G, New F, German R, Emmert L, Sandusky G, Storniolo AM (CPC), Liu Y (CPC), Nakshatri H (CBM). Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry. Nat Med. 2024 DEC 01; 30(12):3482-3494. DOI: 10.1038/s41591-024-03011-9. 2024 Aug 9. PubMed PMID: 39122969; PMCID: PMC11976273.
Lanzloth R (TT), Harris NL, Cannon AM (TT), Kaplan MH (CBM), O'Hagan HM (CBM). Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition. Oncogene. 2025 NOV 01; 44(45):4391-4404. DOI: 10.1038/s41388-025-03589-5. 2025 Oct 2. PubMed PMID: 41039118; PMCID: PMC12583129.
Dai H, Li Y, Lee YA, Lu Y, George TJ, Donahoo WT, Lee KP (EDT), Nakshatri H (CBM), Allen J, Guo Y, Sun RC, Guo J, Bian J (CPC). GLP-1 Receptor Agonists and Cancer Risk in Adults With Obesity. JAMA Oncol. 2025 OCT 01; 11(10):1186-1193. DOI: 10.1001/jamaoncol.2025.2681. PubMed PMID: 40839273; PMCID: PMC12371547.
Luo M (RT/CBM), Yang J, Schäffer AA, Chen C (TT), Liu Y (CPC), Chen Y, Lin C, Diao L, Zang Y (UA), Lou Y, Salman H (HHM), Mills GB, Ruppin E, Han L (HHM). Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations. Cancer Discov. 2025 MAR 03; 15(3):511-529. DOI: 10.1158/2159-8290.CD-24-0827. PubMed PMID: 39601595; PMCID: PMC11875934.
Benam SR, Wang X, Maleknia S (TT), Kapur R (CBM), Shahbazi R (CBM). Enhanced hematopoietic stem cell self-renewal and engraftment through human lung exosomal communication. Mol Ther. 2025 NOV 05; 33(11):5704-5720. DOI: 10.1016/j.ymthe.2025.08.020. 2025 Aug 11. PubMed PMID: 40798884; PMCID: PMC12628159.
Ladaika CA, Chakraborty A, Masood A (EDT), Hostetter G, Yi JM, O'Hagan HM (CBM). LSD1 inhibition attenuates targeted therapy-induced lineage plasticity in BRAF mutant colorectal cancer. Mol Cancer. 2025 APR 23; 24(1):122. DOI: 10.1186/s12943-025-02311-z. 2025 Apr 23. PubMed PMID: 40264166; PMCID: PMC12016338.
Keith B, Welch DR, Agarwal N, Blair C, Chukwudozie IB, Shevde LA, Boise LH, Burnstein KL, Antalis TM, O'Connor KL, Dalal SN, Ellis S, Nakshatri H (CBM). Challenges and opportunities in training cancer researchers. Nat Cancer. 2025 FEB 01; 6(2):223-225. DOI: 10.1038/s43018-024-00872-4. PubMed PMID: 39747649.
Stojanovic L, Abbotts R, Tripathi K, Coon CM, Rajendran S (EDT), Abbasi Farid E, Hostetter G, Guarnieri JW, Wallace DC, Liu S, Wan J (UA), Calendo G, Marker R, Gohari Z, Inayatullah MMA, Tiwari VK, Kader T, Santagata S, Drapkin R, Kommoss S, Pfisterer J, Konecny GE, Coopergard R, Issa JJ, Winterhoff BJN, Topper MJ, Sandusky GE, Miller KD (EDT), Baylin SB, Nephew KP (CBM), Rassool FV. ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer. Cancer Res. 2025 APR 03; 85(7):1183-1198. DOI: 10.1158/0008-5472.CAN-24-1286. PubMed PMID: 39804147; PMCID: PMC11968244.
Mitchell DK, Brewster K, Jiang L, Mang H, Bessler WK, Li X, Lu Q, Qian S, York E, Morrow SK, Dixon SAH, Davis C, Chan KK, Smith A, Flint AC, Le VV, Geisinger A, Enane F, Nabet B, Rhodes SD (CBM), Angus SP (EDT), Clapp DW (CBM). Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis. Sci Adv. 2026 JAN 30; 12(5):eady8382. DOI: 10.1126/sciadv.ady8382. 2026 Jan 30. PubMed PMID: 41616055; PMCID: PMC12857737.
Park SJ, Lukkes JL, Chan KK, Drozd HP, Burgin CB, Qian S, Sullivan MM, Guevara CG, Cunningham N, Arenas S, Collins MA, Zucker J, Won J, Smith A, Jiang L, Mitchell DK, Rhodes SD (CBM), Angus SP (EDT), Clapp DW (CBM). A haploinsufficiency restoration strategy corrects neurobehavioral deficits in Nf1+/- mice. J Clin Invest. 2025 JUL 01; 135(13). DOI: 10.1172/JCI188932. 2025 Jul 1. PubMed PMID: 40590220; PMCID: PMC12208548.
Yang J, Singh N (TT), Xu C, Kong D, Sharma S, Liu S, Lechner J, Lkhagva A, Tan H, Wu Z, Richer MJ (CBM), Zang Y (UA), Huang X (EDT), Kapur R (CBM), Wan J (UA), High AA, Zhang X (EDT), Wang X, Lu X, Yang K (CBM). STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity. Sci Adv. 2025 SEP 26; 11(39):eadx5495. DOI: 10.1126/sciadv.adx5495. 2025 Sep 26. PubMed PMID: 41004572; PMCID: PMC12466853.
Wang Q, Adams EL, Poole RA, Soleimani T, Wang GX (TT), Li H, Capitano ML (CBM), Masood A (EDT), Abrams SI, Lee KP (EDT), Zhang S, Opyrchal M (EDT). Iron diminishes immunosuppressive macrophages and enhances anti-PD-1 immunotherapy in breast cancer models. J Exp Clin Cancer Res. 2026 FEB 12; . DOI: 10.1186/s13046-026-03661-2. 2026 Feb 12. PubMed PMID: 41673739.
Mitchell DK, Brewster K, Makri SC, Khan J, Albright EA, Horvai A, Mang H, Lu Q, Dixon SAH, White E (TT), Saadatzadeh MR (RT/CBM), Bijangi-Vishehsaraei K, Gampala S (RT/EDT), Hickey BE, Leffew H, Li X, Jiang L, Ciesielski MD, Bessler WK, Collier CD (CBM), Cohen-Gadol A, Fishel ML (CBM), Pratilas CA, Pollok KE (EDT), Angus SP (EDT), Rhodes S (CBM), Clapp DW (CBM). DLK1 Distinguishes Subsets of NF1-Associated Malignant Peripheral Nerve Sheath Tumors with Divergent Molecular Signatures. Clin Cancer Res. 2025 MAY 15; 31(10):1988-2009. DOI: 10.1158/1078-0432.CCR-24-3029. PubMed PMID: 40063513; PMCID: PMC12081192.
Wang X, Ramdas B, Kumar R, Zhang J (CBM), Kapur R (CBM). Suppression of Rho-associated kinase 1 (ROCK1) promotes human hematopoietic stem cell expansion by attenuating mitochondrial fission. Leukemia. 2025 NOV 01; 39(11):2825-2829. DOI: 10.1038/s41375-025-02770-9. 2025 Sep 16. PubMed PMID: 40958034; PMCID: PMC12531631.
Inflammatory Bowel Disease-induced Inflammation Augments Clonal Hematopoiesis of Indeterminate Potential through Ref-1. Kumar R, Li L, Urbut S, Uddin MM, Niroula A, Kanumuri R, Ramdas B, Pasupuleti SK, Palam LR, Wang X, Padam KSR, Kelley MR, Natarajan P, Yu Z, Kapur R (CBM). Blood. 2026 Feb 25:blood.2025032339. doi: 10.1182/blood.2025032339. Online ahead of print. PMID: 41746260.
Heidarian Y, Fasteen TD, Mungcal L, Buddika K, Mahmoudzadeh NH, Nemkov T, D'Alessandro A, Tennessen JM (CBM). Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster. Mol Metab. 2025 MAR 01; 93:102106. DOI: 10.1016/j.molmet.2025.102106. 2025 Jan 31. PubMed PMID: 39894213; PMCID: PMC11869853.
