Cancer Biology & Microenvironment Research & Clinical Trials

2024

Stieglitz E, Lee AG, Angus SP (EDT), Davis C, Barkauskas DA, Hall D, Kogan SC, Meyer J, Rhodes SD (CBM), Tasian SK, Xuei X, Shannon K, Loh ML, Fox E, Weigel BJ. Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: a Report from the Children's Oncology Group. Cancer Discov. 2024 SEP 04; 14(9):1590-1598. DOI: 10.1158/2159-8290.CD-23-1376. PubMed PMID: 38867349; PMCID: PMC11374478. 

Zhang D, Schroeder A, Yan H, Yang H, Hu J, Lee MYY, Cho KS, Susztak K, Xu GX, Feldman MD (CBM), Lee EB, Furth EE, Wang L, Li M. Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology. Nat Biotechnol. 2024 SEP 01; 42(9):1372-1377. DOI: 10.1038/s41587-023-02019-9. 2024 Jan 2. PubMed PMID: 38168986; PMCID: PMC11260191. 

Ladaika CA, Ghobashi AH (TT), Boulton WC, Miller SA, O'Hagan HM (CBM). LSD1 and CoREST2 Potentiate STAT3 Activity to Promote Enteroendocrine Cell Differentiation in Mucinous Colorectal Cancer. Cancer Res. 2024 OCT 04; . DOI: 10.1158/0008-5472.CAN-24-0788. 2024 Oct 4. PubMed PMID: 39365378. 

Yu T (CBM), Van der Jeught K, Zhu H, Zhou Z, Sharma S (CBM), Liu S, Eyvani H (TT), So KM, Singh N (TT), Wang J, Sandusky GE, Liu Y (CPC), Opyrchal M (EDT), Cao S, Wan J (UA), Zhang C, Zhang X (EDT). Inhibition of Glutamate-to-Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells. Adv Sci (Weinh). 2024 OCT 31; :e2310308. DOI: 10.1002/advs.202310308. 2024 Oct 31. PubMed PMID: 39482885. 

Khaliq AM, Rajamohan M, Saeed O, Mansouri K, Adil A, Zhang C, Turk A (EDT), Carstens JL, House M, Hayat S, Nagaraju GP, Pappas SG, Wang YA (EDT), Zyromski NJ, Opyrchal M (EDT), Lee KP (HHM), O'Hagan H (CBM), El Rayes B, Masood A (EDT). Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity. Nat Genet. 2024 NOV 01; 56(11):2455-2465. DOI: 10.1038/s41588-024-01914-4. 2024 Sep 18. PubMed PMID: 39294496. 

2023

Flint AC, Mitchell DK, Angus SP (EDT), Smith AE, Bessler W, Jiang L, Mang H, Li X, Lu Q, Rodriguez B, Sandusky GE, Masters AR, Zhang C (CBM), Dang P, Koenig J, Johnson GL, Shen W, Liu J, Aggarwal A, Donoho GP, Willard MD, Bhagwat SV, Clapp DW (HHM), Rhodes SD (CBM). Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma. Clin Cancer Res. 2023 SEP 01; 29(17):3438-3456. DOI: 10.1158/1078-0432.CCR-22-2854. PubMed PMID: 37406085. 

Mondal T, Gaur H, Wamba BEN, Michalak AG, Stout C, Watson MR, Aleixo SL, Singh A, Condello S (CBM), Faller R, Leiserowitz GS, Bhatnagar S, Tushir-Singh J. Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer. Cell Death Differ. 2023 NOV 01; 30(11):2408-2431. DOI: 10.1038/s41418-023-01229-7. 2023 Oct 14. PubMed PMID: 37838774; PMCID: PMC10657439. 

Dasgupta A (CBM), Gibbard DF, Schmitt RE, Arneson-Wissink PC, Ducharme AM, Bruinsma ES, Hawse JR, Jatoi A, Doles JD (CBM). A TGF-β/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer. Proc Natl Acad Sci U S A. 2023 AUG 22; 120(34):e2215095120. DOI: 10.1073/pnas.2215095120. 2023 Aug 16. PubMed PMID: 37585460; PMCID: PMC10462925. 

Mijit M, Kpenu E, Chowdhury NN, Gampala S (EDT), Wireman R, Liu S, Babb O, Georgiadis MM, Wan J (UA), Fishel ML (CBM), Kelley MR (EDT). In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer. Redox Biol. 2023 DEC 01; 69:102977. DOI: 10.1016/j.redox.2023.102977. 2023 Dec 1. PubMed PMID: 38056311; PMCID: PMC10749280. 

Kumar B, Khatpe AS (TT), Guanglong J, Batic K, Bhat-Nakshatri P, Granatir MM, Addison RJ, Szymanski M, Baldridge LA, Temm CJ, Sandusky G, Althouse SK, Cote ML (CPC), Miller KD (EDT), Storniolo AM (CPC), Nakshatri H (CBM). Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent. Nat Commun. 2023 SEP 14; 14(1):5683. DOI: 10.1038/s41467-023-41473-6. 2023 Sep 14. PubMed PMID: 37709737; PMCID: PMC10502140.

• 2023 RNA Editing Gordon Research Conference
• 2022 Bioorganic Chemistry Gordon Research Conference

Hari Nakshatri, BVSc, PhD

• Invited speaker at the 15th AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Philadelphia, September 16-19, 2022.

Edward Greenfield, PhD

• The Hdac Inhibitor Romidepsin Is A Promising Therapeutic For Metastatic Osteosarcoma (presentation given by Emily Seiden), Annual Meeting of the Orthopaedic Research Society. Featured in Orthopedics Today: https://www.healio.com/news/orthopedics/20220210/video-romidepsin-linked-with-reduced-size-viability-of-osteosarcoma-sarcospheres

Richard Carpenter, MD 

• Jacobs CL, Sha SV, Lu WC, Ray H, Carpenter RL. HSF1 downregulation of CCL5 reduces CD8+ T cell trafficking in breast cancer. AACR Annual Meeting 2022. 04/2022. New Orleans, LA. Oral Presentation.

1. Inhibition of LNCRNA HOTAIR and Related Materials and Methods. Kenneth P. Nephew and Ali Rayet Ozes, Patent No.: US 10,801,024 B2; Date of Patent:  13, 2020
2. Methods of Targeting APE1/Ref-1 to Inhibit Hypoxia Signaling Genes, Mark R. Kelley and Melissa L. Fishel, Patent Number 2016262985, IP Australia, June 21, 2021.