Inclusion Criteria:
To enroll in Cohort A, a subject must:
- Be 45-80 years of age (inclusive) at the time of screening.
- Be recently diagnosed with primary colorectal cancer or advanced adenoma with plans to
surgically remove the target lesion.
To enroll in Cohort B, a subject must:
- Be 45-80 years of age (inclusive) at the time of screening.
- Be planning to undergo a screening colonoscopy within 30 days after providing signed
informed consent.
Exclusion Criteria:
To enroll in Cohort A, a subject must NOT have:
- Inflammatory bowel disease (IBD)
- Personal or family history of colorectal cancer syndromes or other hereditary cancer
syndromes
To enroll in Cohort B, a subject must NOT have:
- Personal history of colorectal cancer, colorectal adenoma or aerodigestive tract
cancer.
- Personal or family history of Familial adenomatous polyposis (FAP).
- Personal or family history of Hereditary non-polyposis colorectal cancer syndrome
(HNPCC or Lynch Syndrome).
- Positive fecal occult blood testing (FOBT) within the previous 6 months.
- Positive fecal immunochemical testing (FIT) in the previous 6 months.
- Colorectal resection for any reason other than sigmoid diverticular disease.
- Overt rectal bleeding within the previous 30 days.
- Personal history of any cancer diagnosed <5 years prior.
- Inflammatory bowel disease (IBD), including chronic ulcerative colitis (CUC) and
Crohn's disease.
- Colonoscopy within the previous 9 years.
- Barium enema, computed tomographic colonography, or sigmoidoscopy within the previous
5 years.
- ≥ 2 first-degree relatives who have been diagnosed with colorectal cancer (Note: First
degree relatives include parents, siblings and offspring).
- 1 first-degree relative with CRC diagnosed before the age of 60.
- Have participated or be currently participating in a clinical research study in which
an experimental medication has been administered during the 30 days up to and
including the date of providing informed consent or may be administered through the
time of the colonoscopy.
- Have a medical condition which, in the opinion of the investigator, should preclude
enrollment into the study.