Inclusion Criteria:
1. ≥ 18 years old at the time of informed consent
2. Written informed consent and HIPAA authorization for release of personal health
information.
3. Subjects with histologically and radiographically confirmed NSCLC.
4. Subjects must have stage IV disease or recurrent disease.
5. Subjects should be treatment naïve (systemic therapies) or have received prior
chemotherapy in the first line setting. Prior radiation or surgery is permissible.
6. Subjects who are eligible to receive single agent immunotherapy must have
documentation of a PD-L1 Tumor Proportion Score (TPS) of at least 1%.
7. Subjects with Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
Exclusion Criteria:
1. Subjects with curable or potentially curable NSCLC.
2. Subjects should not have contraindications to treatment with immune checkpoint
inhibitors per standard criteria.
3. Patients with targetable mutations eligible for treatment with molecularly targeted
small molecule inhibitor therapy.
4. Subjects eligible for combination treatment with chemoimmunotherapy.