Member Biography

Simon J. Conway

Simon Conway

1044 W. Walnut Street
R4 379
Indianapolis, IN 46202

Phone: (317) 278-8780

Research Program Membership

Department of Pediatrics
IU School of Medicine

Department of Anatomy and Cell Biology
IU School of Medicine

Dr. Conway's laboratory has a single common aim - to understand congenital abnormalities and to identify the underlying in utero pathogenesis of birth and postnatal defects. Dr. Conway is mainly focused of the neural crest cell lineage which normally contributes to the cardiovascular and nervous systems but whose deregulation causes devastating congenital cardiovascular and neuronal defects which underlie multiple neonatal heart defects and childhood diseases. He uses transgenic mice as models of human disease (Pax transcription factors involved in Waardenburg syndrome and neuroectodermal tumors; Neurofibromin involved in NF1 and NF2 neurofibroma, schwannoma and various vasculopathies; and the TGFbeta superfamily in tumor niche establishment). His group is investigating when development first goes wrong (both in utero and postnatally), identifying the cell lineages responsible (using various reporter lineage mapping mice) and then attempting to correct and/or alleviate the various structural and dysfunctional anomalies observed. If these experimentally induced congenital diseases can be prevented and/or nullified in genetically-defined mouse mutant models, he then hopes to apply the knowledge gained to help engineer potential treatments for patients.

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Post-doctoral Fellowship - University College London (IHC), England 1993-1996

Ph.D. - University College London (MRC), England 1989-1993