Tumor Microenvironment & Metastasis

Tumor LabTumor Microenvironment and Metastasis (TMM) research program supports the cancer center's mission to lead the battle against cancer throughout the State of Indiana with three goals. First, we advance the basic understanding of the role of cancer cell–stroma interactions in cancer initiation, progression and metastasis. Second, we study mechanisms of the systemic consequences of metastatic disease, particularly on muscle and bone dysfunction as well as metabolism. Third, TMM is a basic science research program whose discoveries lead to clinical trials conducted in collaboration with EDT and CPC.

The program has two themes:

Theme 1: Tumor-stromal cell interactions in the tumor microenvironment and at metastatic sites:

  • Aim 1: To identify pathway-driven and molecular targets of tumor-stromal crosstalk.
  • Aim 2: To develop novel models for the study of the tumor microenvironment.

Theme 2: Systemic consequences of metastases and treatment:

  • Aim 1: To elucidate the molecular underpinnings of cancer-associated muscle dysfunction.
  • Aim 2: To identify mechanisms and consequences of cancer-induced bone destruction.