Tumor Microenvironment & Metastasis

Tumor LabTumor Microenvironment and Metastasis (TMM) research program supports the cancer center's mission to lead the battle against cancer throughout the State of Indiana with three goals. First, we advance the basic understanding of the role of cancer cell–stroma interactions in cancer initiation, progression and metastasis. Second, we study mechanisms of the systemic consequences of metastatic disease, particularly on muscle and bone dysfunction as well as metabolism. Third, TMM is a basic science research program whose discoveries lead to clinical trials conducted in collaboration with EDT and CPC.

The program has two themes:

Theme 1: Tumor-stromal cell interactions in the tumor microenvironment and at metastatic sites.

  • Aim 1: To identify pathways and molecular targets of tumor-host crosstalk.
  • Aim 2: To develop novel models for the study of the tumor microenvironment.

Theme 2: Systemic consequences of tumor, metastases and treatment in the macroenvironment of the host.

  • Aim 1: To identify pathways and molecular targets of tumor-host crosstalk.
  • Aim 2: To develop novel models for the study of the tumor macroenvironment.