My research was focused on the DNA damage signaling pathway and human cancer. I identified a number of key regulators in the DNA damage pathway including miRNAs, protein phosphatases and deubiquitinases. In particular, I identified KSRP as a first key player that links DNA damage signaling to microRNA biogenesis (Mol Cell, 2011). Recently, we identified two potential oncogenes, WIP1 and MIR21 in the 17q23 region which is frequently amplified in human breast cancer. Our study found that miR-21 and Wip1 contribute to drug resistance in anti-HER2 therapies by inhibiting PTEN and p53 tumor suppression pathways. We will examine whether inhibiting Wip1 and miR-21 will sensitize Her2+ breast tumors to trastuzumab treatment in breast cancer mouse model.
Post-doctoral Fellowship - Baylor College of Medicine, Houston, TX 2003-2007
Post-doctoral Fellowship - Baylor College of Medicine, Houston, TX 2001-2003
PHMD - Shanghai Institute of Biochemistry, China 1996-2001