Research and development of drugs and new chemical entities
The Clinical Pharmacology Analytical Core (CPAC) facilitates the research and development of drugs and new chemical entities in support of internal and external investigators including:
- IU Simon Comprehensive Cancer Center
- IU School of Medicine
- Purdue University Institute for Cancer Research
- The Indiana CTSI
Our primary service is to develop methods to quantify small molecule drugs, metabolites, and new chemical entities (NCEs) from a variety of biological matrices by utilizing our state-of-the-art ultra-performance liquid chromatography tandem mass spectrometers (UPLC-MS/MS).
We assist investigators by providing detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, and drug purity verification.