Research and development of drugs and new chemical entities
The Clinical Pharmacology Analytical Core (CPAC) facilitates the research and development of drugs and new chemical entities (NCEs) in support of internal and external investigators—in particular, members from:
- IU Simon Comprehensive Cancer Center
- IU School of Medicine
- Purdue University Center for Cancer Research
Our primary service is developing methods to quantify drugs, metabolites, and NCEs from a variety of biological matrices by utilizing our state-of-the-art ultra-performance liquid chromatography tandem mass spectrometer (UPLC-MS/MS).
We assist investigators by providing detailed information on in vivo pharmacokinetics (PK), drug interactions, in vitro drug metabolic stability, formulation optimization, protein binding, and drug purity verification.