Cancer Bioinformatics

The mission of the Cancer Bioinformatics Core is to enable IU Simon Cancer Center investigators to take full advantage of rapidly developing high-throughput technologies to perform ‘omics’ cancer research, from the basic molecular studies to translational and clinical investigations.

The core promotes and supports investigator-centric collaborations, not only within the IU Simon Cancer Center, but also with the Purdue University Center for Cancer Research.

The core's aims are:

Specific Aim 1: To deliver expert bioinformatics service and data analysis to assist in discovery, identification, and characterization of the genes, mutations, pathways, biomarkers, therapeutic targets and drugs specific to the cancer studies conducted by IU Simon Cancer Center investigators. The core works closely with individual cancer research programs to address their specific needs. In addition, the CBC works with the Regenstrief Institute and Data Science and Informatics Initiative of the IU Precision Health Initiative by providing expert support on genomics analysis, integration of genomic data with clinical data to inform novel, testable hypothesis from the cancer precision medicine clinic to the laboratory bench for further innovation.

Specific Aim 2: To expand the capacity on methodology innovation and infrastructure of the CBC. The core works on bioinformatics methodology and tool development for new technologies, such as CRISPR/Cas9 and ATAC-seq, to meet investigators’ increasing needs. The core also develops vision and strategies for mining, learning, integrating and visualizing large public domain datasets from projects such as the Cancer Genome Atlas (TCGA), the Cancer Cell Line Encyclopedia (CCLE), and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) to complement data from IUSCC for cancer research.

Specific Aim 3: To provide regular bioinformatics training and education to IU Simon Cancer Center researchers, clinicians and students in addition to serving as a resource for consultations. The CBC will supply bioinformatics training workshops, particularly to data analysts in IUSCC investigators’ labs, to help them learn state-of-art in bioinformatics tools and obtain hands-on experience on accessing and analyzing data from different resources.