"Near-Miss" NCI Initiative

IUSCC Support for High Quality Grant Applications Missing NCI Payline

Purpose: To provide funding to support IUSCC PI-directed applications to the National Cancer Institute with high potential for obtaining external funding that have been reviewed once or twice and missed the NCI payline. The goal is to increase the NCI funding base in the IUSCC.


Applicants must:

  • Be a member of the IUSCC; if a junior investigator, must be past the start-up period
  • Have a NCI R01 or R21application that scored equal to or below twice the current NCI pay line (e.g. Investigators receiving a 25% or better percentile on a NCI RO1 or R21 application upon first submission); or those scoring a 20% following second submission.
  • Have submitted his/her original NCI grant in 2013 or later be considered
  • Submit request for IUSCC funding only one time per grant (i.e. can't get a 25% first review and then </=20% for same grant on second NIH review and apply for money twice.)

Note: Only NIH R01 and R21 applications will be considered. Only grants submitted to NCI. No exceptions.

Applications for funding must include:
  • A cover letter describing the rationale for the request and the planned timeline for resubmission of the grant application.
  • A one-page proposal for use of the funding to include a timeline and/or map (via ITRAC mechanism) for accomplishing the proposed work and identified benchmarks necessary for high likelihood for achieving a fundable score upon new submission
  • A proposed budget and justification for the funding. (Maximum allowable amount for RO1 grants is $50K and R21 $30K).
  • Specific Aims page of the originally submitted grant application
  • The reviewer critiques of the application with score and percentile.
  • The proposed responses to those critiques and plans on how the application will be converted to a new application for submission.
Review Process
  • Review of application and funding will be performed by a committee comprised of the IUSCC Program Leaders and a final review for determination of funding will be performed by the IUSCC Executive Committee.
  • Applications must be either NCI R01 or R21 exclusively. No exceptions.
  • Submission can be at any time. Expedited review for early resubmission or off-cycle reviews can be requested.
  • The review committee will consider the overall probability of future funding for the project as reflected in the priority score, reviewer critiques, response of the PI to those critiques, and how the application will be modified for submission as a new application.
  • Additionally, evaluation will include demonstrated ongoing efforts of the PI in obtaining funding for the project (e.g. list of grant applications submitted within the past year), and the level of involvement of the PI in the IUSCC. Each application will be considered on its own merit.
Post-award management

After an award is made, the project must be mapped (contact Crystal Munson) and an interim progress report will be required to determine if the funds are being used as originally proposed, milestones are being achieved, and the timeline is on-target.

Contact information

Crystal Munson for submission support (mapping/timeline) or Mark R. Kelley for inquires.