June 16, 2026
</header><main><div class="content-top"><div class="section breadcrumbs"><div class="row"><div class="layout"><ul itemscope="itemscope" itemtype="http://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../index.html" itemprop="item"><span itemprop="name">Home</span></a><meta content="1" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../index.html" itemprop="item"><span itemprop="name">Education & Training</span></a><meta content="2" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="index.html" itemprop="item"><span itemprop="name">Education & Training Events</span></a><meta content="3" itemprop="position"/></li><li class="current" itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><span itemprop="name">Cancer Burden Across Indiana</span><meta content="4" itemprop="position"/></li></ul></div></div></div><div class="section page-title bg-none"><div class="row"><div class="layout"><h1>Cancer Burden Across Indiana</h1></div></div></div></div><div id="main-content"><div class="bg-none section" id="content"><div class="row"><div class="layout"><h2 class="section-title">Cancer Burden Across Indiana: Connecting Molecular Mechanisms to Treatment, Care, and Community Symposium</h2><div class="text"><p>The 2026 Cancer Burden Across Indiana: Connecting Molecular Mechanisms to Treatment, Care, and Community Symposium will be held Tuesday, June 16 in Indianapolis.</p><p>The goal of the symposium is to identify ongoing research, gaps, and foster collaboration in research focused on disease variability, clinical care, and community engagement at Indiana University and Indiana.</p><p>The symposium welcomes IU clinical and research faculty, staff, and trainees as well as participants from other Indiana colleges and universities. Community members, including patient advocates, industry representatives, community partners, and external board members, are also encouraged to attend.</p><p>Students, fellows, faculty, and staff engaged in cancer research or clinical care are invited to present their work, particularly in areas such as social, genetic and biological determinants of health, healthcare for all, culturally aware research practices, community engagement, health policy, and variabilities in cancer outcomes.</p><p>The deadline to submit an abstract is May 15, 2026. The registration deadline is June 8, 2026.</p></div></div><!-- /.layout --></div></div><div class="bg-crimson bg-dark section"><div class="row"><div class="layout"><div class="text text-center cta"><a class="button" href="https://redcap.link/CBAI2026">Register Now</a></div></div><!-- /.layout --></div></div><div class="bg-none section"><div class="row"><div class="layout"><div class="text"><p>For questions about the symposium, please contact <a href="mailto:djengell@iu.edu">Daenique Jengelley</a>, PhD, and for assistance with registration and abstract submission, please contact <a href="mailto:stverhag@iu.edu">Steven Verhagen</a>.</p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><div class="text"><h3 style="text-align: center;">Cancer Burden Across Indiana: Connecting Molecular Mechanisms to Treatment, Care, and Community</h3><p style="text-align: center;">Symposium will be held in Walther Hall (980 W. Walnut St.)<br/>Parking will be validated for the Lockefield Garage (951 Wishard Blvd.)<br/>June 16, 2026</p><p style="text-align: center;"><a class="button" href="https://cpf.iu.edu/doc/iupui_full_11x17.jpg" rel="noopener" target="_blank">Campus map</a></p></div></div><!-- /.layout --></div></div><div class="bg-none section"><div class="row"><div class="layout"><h3 class="section-title">Agenda</h3><div class="text"><table><tbody><tr><td style="min-width: 195px; vertical-align: top;"><p>7:15 a.m.</p></td><td style="width: 573px;"><p><strong>Registration Opens </strong><em>(Walther, Atrium)</em><em></em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>7:35 - 8:25 a.m.</p></td><td style="width: 573px;"><p><strong>Breakfast Roundtables</strong><em>(Walther, 303)</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>8:35 - 8:50 a.m.</p></td><td style="width: 573px;"><p><strong>Welcome Remarks</strong><em>(Walther, 203) <br/>Eric Vachon, PhD, Assistant director, Office of Institutional Effectiveness </em><em></em><em></em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>8:50 - 9:50 a.m.</p></td><td style="width: 573px;"><p><strong>Keynote Fireside Chat </strong>( <em>Walther, 203) <br/></em>Keynote: John Allen, PharmD<br/><em>“From Cancer Burden to Supportive Cancer Care: Antidepressant Use, Social Context, and Pathways to Better Outcomes”</em><br/>Moderator: Kathi Ridley-Merriweather, PhD   </p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>9:50 - 10 a.m.</p></td><td style="width: 573px;"><p><strong>Break</strong></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10 - 11 a.m.</p></td><td style="width: 573px;"><p><strong>Plenary Session </strong><em>(Walther, 203)</em></p><p><strong>Integrating Molecular, Clinical, and Community Approaches to Improve Cancer Outcomes</strong></p><p>Moderators: Dr. Charlie Dong and Mr. Kwadwo Fosu </p><table><tbody><tr><td style="width: 195px; vertical-align: top;"><p>10 - 10:15 a.m.</p></td><td><p><strong>Mr. Ken Virgin:</strong><em>“Barriers to Adjuvant Treatment for Newly Diagnosed Pediatric Brain Tumors in the Molecular Era: A Single Center Retrospective Study”  </em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10:15 - 10:30 a.m.</p></td><td><p><strong>Ms. Allison Ellis:</strong><em>“Identifying Factors Associated with Mammogram Screening Among Women Surveyed at a Student-run Community Outreach Clinic”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10:30 - 10:45 a.m.</p></td><td><p><strong>Dr. Janet Panoch:</strong><em>“Why the Patient-Powered Registry Is Crucial for People with Rare Conditions: We Need as Much Research as We Can Get!”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10:45 - 11 a.m.</p></td><td><p><strong>Q&A</strong></p></td></tr></tbody></table></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>11:05 - 11:50 a.m.</p></td><td style="width: 573px;"><p><strong>Lunch</strong><em> (Walther, Atrium)</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>11:50 a.m. - 1 p.m.</p></td><td style="width: 573px;"><p><strong>Poster Session </strong>(Walther, Atrium)</p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:05 - 1:45 p.m.</p></td><td style="width: 573px;"><p><strong>Plenary Session</strong></p><p><strong>Connecting Bench to Bedside to Community: Enhancing Cancer Prevention and Treatment</strong><em>(Walther, 203)</em></p><p>Moderators: Dr. Janet Panoch and Mr. Venkatesh Joshi</p><table><tbody><tr><td style="width: 195px; vertical-align: top;"><p>1:05 - 1:15 p.m.</p></td><td><p><strong>Dr. Sanya Haiaty:</strong><em>“Gata2T354M hemizygosity cooperates with bi-allelic Cebpa deletions to initiate AML”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:15 - 1:25 p.m.</p></td><td><p><strong>Dr. Janet Panoch:</strong><em>“Shared Decision Making from Bench to Bedside to Community: The History of a Successful Patient Decision Aid”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:25 - 1:35 p.m.</p></td><td><p><strong>Dr. Ali Ajrouch:</strong><em>“Leveraging mammography to increase lung cancer screening: evaluation of a pilot print-to-web outreach intervention”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:35 - 1:45 p.m.</p></td><td><p><strong>Q&A</strong></p></td></tr></tbody></table></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:45 - 2 p.m.</p></td><td style="width: 573px;"><p><strong>Closing Remarks </strong><em>(Walther, 203)</em> </p><p>Dr. Eric Vachon, Asst. Director for Office of Inclusive Excellence</p></td></tr></tbody></table><p> </p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><h3 class="section-title">Thank you to our sponsors!</h3><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/cancer_burden_across_indiana/indiana_university_research-lockup-174x50.webp"/></figure><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/cancer_burden_across_indiana/black_philanthropy_circle-lockup-375x50.webp"/></figure><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/cancer_burden_across_indiana/womens_philanthropy_leadership_council-lockup-563x50.webp"/></figure></div><!-- /.layout --></div></div>
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June 16
</header><main><div class="content-top"><div class="section breadcrumbs"><div class="row"><div class="layout"><ul itemscope="itemscope" itemtype="http://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../index.html" itemprop="item"><span itemprop="name">Home</span></a><meta content="1" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../index.html" itemprop="item"><span itemprop="name">Education & Training</span></a><meta content="2" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="index.html" itemprop="item"><span itemprop="name">Education & Training Events</span></a><meta content="3" itemprop="position"/></li><li class="current" itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><span itemprop="name">Cancer Burden Across Indiana</span><meta content="4" itemprop="position"/></li></ul></div></div></div><div class="section page-title bg-none"><div class="row"><div class="layout"><h1>Cancer Burden Across Indiana</h1></div></div></div></div><div id="main-content"><div class="bg-none section" id="content"><div class="row"><div class="layout"><h2 class="section-title">Cancer Burden Across Indiana: Connecting Molecular Mechanisms to Treatment, Care, and Community Symposium</h2><div class="text"><p>The 2026 Cancer Burden Across Indiana: Connecting Molecular Mechanisms to Treatment, Care, and Community Symposium will be held Tuesday, June 16 in Indianapolis.</p><p>The goal of the symposium is to identify ongoing research, gaps, and foster collaboration in research focused on disease variability, clinical care, and community engagement at Indiana University and Indiana.</p><p>The symposium welcomes IU clinical and research faculty, staff, and trainees as well as participants from other Indiana colleges and universities. Community members, including patient advocates, industry representatives, community partners, and external board members, are also encouraged to attend.</p><p>Students, fellows, faculty, and staff engaged in cancer research or clinical care are invited to present their work, particularly in areas such as social, genetic and biological determinants of health, healthcare for all, culturally aware research practices, community engagement, health policy, and variabilities in cancer outcomes.</p><p>The deadline to submit an abstract is May 15, 2026. The registration deadline is June 8, 2026.</p></div></div><!-- /.layout --></div></div><div class="bg-crimson bg-dark section"><div class="row"><div class="layout"><div class="text text-center cta"><a class="button" href="https://redcap.link/CBAI2026">Register Now</a></div></div><!-- /.layout --></div></div><div class="bg-none section"><div class="row"><div class="layout"><div class="text"><p>For questions about the symposium, please contact <a href="mailto:djengell@iu.edu">Daenique Jengelley</a>, PhD, and for assistance with registration and abstract submission, please contact <a href="mailto:stverhag@iu.edu">Steven Verhagen</a>.</p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><div class="text"><h3 style="text-align: center;">Cancer Burden Across Indiana: Connecting Molecular Mechanisms to Treatment, Care, and Community</h3><p style="text-align: center;">Symposium will be held in Walther Hall (980 W. Walnut St.)<br/>Parking will be validated for the Lockefield Garage (951 Wishard Blvd.)<br/>June 16, 2026</p><p style="text-align: center;"><a class="button" href="https://cpf.iu.edu/doc/iupui_full_11x17.jpg" rel="noopener" target="_blank">Campus map</a></p></div></div><!-- /.layout --></div></div><div class="bg-none section"><div class="row"><div class="layout"><h3 class="section-title">Agenda</h3><div class="text"><table><tbody><tr><td style="min-width: 195px; vertical-align: top;"><p>7:15 a.m.</p></td><td style="width: 573px;"><p><strong>Registration Opens </strong><em>(Walther, Atrium)</em><em></em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>7:35 - 8:25 a.m.</p></td><td style="width: 573px;"><p><strong>Breakfast Roundtables</strong><em>(Walther, 303)</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>8:35 - 8:50 a.m.</p></td><td style="width: 573px;"><p><strong>Welcome Remarks</strong><em>(Walther, 203) <br/>Eric Vachon, PhD, Assistant director, Office of Institutional Effectiveness </em><em></em><em></em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>8:50 - 9:50 a.m.</p></td><td style="width: 573px;"><p><strong>Keynote Fireside Chat </strong>( <em>Walther, 203) <br/></em>Keynote: John Allen, PharmD<br/><em>“From Cancer Burden to Supportive Cancer Care: Antidepressant Use, Social Context, and Pathways to Better Outcomes”</em><br/>Moderator: Kathi Ridley-Merriweather, PhD   </p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>9:50 - 10 a.m.</p></td><td style="width: 573px;"><p><strong>Break</strong></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10 - 11 a.m.</p></td><td style="width: 573px;"><p><strong>Plenary Session </strong><em>(Walther, 203)</em></p><p><strong>Integrating Molecular, Clinical, and Community Approaches to Improve Cancer Outcomes</strong></p><p>Moderators: Dr. Charlie Dong and Mr. Kwadwo Fosu </p><table><tbody><tr><td style="width: 195px; vertical-align: top;"><p>10 - 10:15 a.m.</p></td><td><p><strong>Mr. Ken Virgin:</strong><em>“Barriers to Adjuvant Treatment for Newly Diagnosed Pediatric Brain Tumors in the Molecular Era: A Single Center Retrospective Study”  </em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10:15 - 10:30 a.m.</p></td><td><p><strong>Ms. Allison Ellis:</strong><em>“Identifying Factors Associated with Mammogram Screening Among Women Surveyed at a Student-run Community Outreach Clinic”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10:30 - 10:45 a.m.</p></td><td><p><strong>Dr. Janet Panoch:</strong><em>“Why the Patient-Powered Registry Is Crucial for People with Rare Conditions: We Need as Much Research as We Can Get!”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>10:45 - 11 a.m.</p></td><td><p><strong>Q&A</strong></p></td></tr></tbody></table></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>11:05 - 11:50 a.m.</p></td><td style="width: 573px;"><p><strong>Lunch</strong><em> (Walther, Atrium)</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>11:50 a.m. - 1 p.m.</p></td><td style="width: 573px;"><p><strong>Poster Session </strong>(Walther, Atrium)</p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:05 - 1:45 p.m.</p></td><td style="width: 573px;"><p><strong>Plenary Session</strong></p><p><strong>Connecting Bench to Bedside to Community: Enhancing Cancer Prevention and Treatment</strong><em>(Walther, 203)</em></p><p>Moderators: Dr. Janet Panoch and Mr. Venkatesh Joshi</p><table><tbody><tr><td style="width: 195px; vertical-align: top;"><p>1:05 - 1:15 p.m.</p></td><td><p><strong>Dr. Sanya Haiaty:</strong><em>“Gata2T354M hemizygosity cooperates with bi-allelic Cebpa deletions to initiate AML”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:15 - 1:25 p.m.</p></td><td><p><strong>Dr. Janet Panoch:</strong><em>“Shared Decision Making from Bench to Bedside to Community: The History of a Successful Patient Decision Aid”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:25 - 1:35 p.m.</p></td><td><p><strong>Dr. Ali Ajrouch:</strong><em>“Leveraging mammography to increase lung cancer screening: evaluation of a pilot print-to-web outreach intervention”</em></p></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:35 - 1:45 p.m.</p></td><td><p><strong>Q&A</strong></p></td></tr></tbody></table></td></tr><tr><td style="width: 195px; vertical-align: top;"><p>1:45 - 2 p.m.</p></td><td style="width: 573px;"><p><strong>Closing Remarks </strong><em>(Walther, 203)</em> </p><p>Dr. Eric Vachon, Asst. Director for Office of Inclusive Excellence</p></td></tr></tbody></table><p> </p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><h3 class="section-title">Thank you to our sponsors!</h3><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/cancer_burden_across_indiana/indiana_university_research-lockup-174x50.webp"/></figure><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/cancer_burden_across_indiana/black_philanthropy_circle-lockup-375x50.webp"/></figure><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/cancer_burden_across_indiana/womens_philanthropy_leadership_council-lockup-563x50.webp"/></figure></div><!-- /.layout --></div></div>
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June 20
</header><main><div class="content-top"><div class="section breadcrumbs"><div class="row"><div class="layout"><ul itemscope="itemscope" itemtype="http://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../../index.html" itemprop="item"><span itemprop="name">Home</span></a><meta content="1" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../index.html" itemprop="item"><span itemprop="name">Giving</span></a><meta content="2" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../index.html" itemprop="item"><span itemprop="name">Research Updates</span></a><meta content="3" itemprop="position"/></li><li class="current" itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><span itemprop="name">Testis Cancer</span><meta content="4" itemprop="position"/></li></ul></div></div></div><div class="section page-title bg-none"><div class="row"><div class="layout"><h1>Testis Cancer</h1></div></div></div></div><div id="main-content"><div class="bg-none section" id="content"><div class="row"><div class="layout"><h2 class="section-title">Testis Cancer Research Update</h2><div class="text"><p>A diagnosis of testicular cancer was once almost akin to a death sentence. Over the past 50 years, that’s dramatically changed. The chemotherapy regimen developed by<a href="../../../about/members/bio/3017/index.html"> <strong>Larry Einhorn, MD</strong></a>, has lifted the cure rate to almost 95%. Though that’s impressive, Einhorn and his colleagues at Indiana University are not satisfied and continue a robust research program focused on resistant or recurrent disease and lessening the long-term side effects of treatment.</p></div><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../../images/people/lawrence_einhorn_20220401-768x512-l50.webp"/><figcaption itemprop="caption"><span class="caption-text"><a href="../../../about/members/bio/3017/index.html">Larry Einhorn, MD, </a>Distinguished Professor, Livestrong Foundation Professor of Oncology</span></figcaption></figure><div class="text"><p>Each year, about 8,000 men are diagnosed with testicular cancer. Often, they make their way to Indiana University Melvin and Bren Simon Comprehensive Cancer Center, one of the few places in the world with the expertise and resources to fundamentally alter outcomes. For those men who cannot travel to IU, Einhorn and his team continue to consult directly with patients and their physicians—at no charge—to ensure they are getting the best possible care wherever they are.</p><p>Our research does more than help cure those who turn to us–it changes the standard of care for patients worldwide. With your philanthropic support, we can continue to provide this level of expertise for years to come.</p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><h3 class="section-title">Marking 50 Years of the Cure</h3><div class="text"><p>In 2024, IU marked the <a href="../../../about/news/focus/testicular/celebrating_50_years_of_cure.html">50th anniversary</a> of Einhorn’s groundbreaking discovery. Over the past 50 years, his chemotherapy regimen to treat testicular cancer has saved hundreds of thousands of lives and is widely considered among the greatest achievements in medicine.</p><p>“Even in my wildest youthful exuberance, I never dreamed that this type of therapy would have that type of result,” Einhorn said. “It's the Neil Armstrong walk on the moon. You do something like that once in your professional career.”</p><p>The magnitude of Einhorn’s discovery is quantifiable not only in the hundreds of thousands of lives saved but also through the ripple effect on dozens of oncologists he has trained and a lasting culture of exceptional research and care at the IU Simon Comprehensive Cancer Center.</p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><h3 class="section-title">Treatment Resistant Disease</h3><div class="text"><p>Unfortunately, there are still patients who are not cured by standard or intensive high-dose chemotherapy. Their cancer continues to spread even in the face of intensive treatments.</p></div><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../../images/people/nabil_adra-20231110-768x512.webp"/><figcaption itemprop="caption"><span class="caption-text"><a href="../../../about/members/bio/18627/index.html">Nabil Adra, MD</a>, Associate Professor of Clinical Medicine</span></figcaption></figure><div class="text"><p>Several years ago, IU researchers conducted genomic testing on these patients. The results showed that their cancers often overexpress a certain protein that drives tumor growth. IU researchers immediately began to search for a way to block it.</p><p>In Spring 2021, <strong><a href="../../../about/members/bio/18627/index.html">Nabil Adra, MD</a></strong><a href="https://cancer.iu.edu/about/members/bio/18627/index.html"></a>, launched a clinical trial for a drug he hopes will do just that. The initial plan was to enroll 25 patients, but given early results, the trial was expanded to enroll up to 50 patients from across the country who will take a single pill orally each day. While it is still early, researchers are optimistic.</p><p>Unlike chemotherapy, this drug is a targeted therapy. It spares patients from the draining physical toll that comes with a cisplatin-based protocol. Additionally, patients can stay on the drug, which was initially developed for kidney cancer, if needed. This clinical trial is nearing completing enrollment and the IU team hopes to share results in the near future.</p><p>Investigators are also opening a clinical trial at IU looking at a novel immunotherapy approach to treat patients with refractory—or treatment resistant—testicular cancer. This novel treatment guides our immune system to identify the foreign testicular cancer cells and fight them.  Researchers are excited about this promising trial and the possibility of a new approach to treating patients.</p><p>The IU team is also opening a clinical trial evaluating CAR-T cell therapy in patients with testicular cancer who are not cured with standard regimens. CAR-T is a novel form of immunotherapy where the immune system is harnessed to fight cancer cells.</p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><div class="text"><h3>Relapsed Disease</h3><p>Almost 80 percent of men treated with Einhorn’s chemotherapy regimen are cured after their first round of treatments. Unfortunately, some see their testicular cancer return.</p><p>At Indiana University, the standard protocol for patients with relapsed disease is high-dose chemotherapy and a stem-cell transplant. Studies over the past 20 years have shown that this approach will cure about 60 percent of these patients.</p><p>However, Einhorn and his protégé, Nabil Adra, MD, are looking for ways to boost that cure rate.</p><p>IU is conducting a clinical trial that gives one group of patients the time-tested therapy followed by observation. Another group receives intensive high-dose chemotherapy followed by a chemotherapy drug in pill form for three months as a maintenance therapy. The goal is to understand if this maintenance therapy improves the cure rate compared to men who receive high-dose chemotherapy alone.</p><p>This research is being funded by philanthropic support from donors like you. In many other cancers, pharmaceutical companies are more likely to invest in such trials. That is not the case for a rare disease like testicular cancer, making donor support crucial for researchers to explore ways to advance treatment.</p><p>Patients with testicular cancer who have relapsed disease spread to the brain are particularly difficult to cure. Research led by <strong><a href="../../../about/members/bio/30182/index.html">Jennifer King, MD</a></strong>, showed that these patients can be cured with high-dose chemotherapy and stem-cell transplant. This was presented at the American Society of Clinical Oncology Annual Meeting in June 2024.</p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><h3 class="section-title">Biomarkers</h3><div class="text"><p>The longer cancer goes undetected—and untreated—the more challenging it can be to eliminate. Even when treatment is successful, oncologists need a tool to easily monitor whether the disease is returning.</p><p>Available blood tests are only about 60 percent accurate. However, researchers have identified new potential biomarkers that hold promise. When heavy amounts are circulating in a patient’s bloodstream, it is evidence that a tumor is present.</p><p>IU researchers are developing and optimizing blood tests for these biomarkers, a minimally invasive way for physicians to detect microscopic amounts of testicular cancer. So far, data indicates it is roughly 90 percent accurate.</p><p>Now, scientists are working to clarify how best to interpret the results of this new blood test. For example, a patient with localized disease often undergoes surgery or chemotherapy to prevent cancer from recurring.</p><p>A highly accurate diagnostic test would help us know whether additional procedures such as surgery or chemotherapy are truly required–or whether a patient should be followed with close observation alone.</p><p>IU researchers – led by post-doctoral research fellow <strong>Rebecca Hassoun, MD</strong> – presented a multi-institutional collaboration evaluating circulating tumor DNA – a novel biomarker that detects tumor DNA in the blood – at the American Society of Clinical Oncology Annual Meeting conference in June 2024.</p><p>Given the positive findings of the study, investigators are hoping to secure funding for a new trial for a larger number of patients so they can expand their dataset and further validate their findings.</p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><div class="text"><h3>Survivorship</h3><p>For most patients, a combination of cisplatin and two other chemotherapy drugs eradicates their disease. Unfortunately, these drugs also have lasting side effects that, for some survivors, can disrupt daily life.</p></div><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../../images/people/lois_travis-768x512.webp"/><figcaption itemprop="caption"><span class="caption-text"><a href="../../../about/members/bio/12422/index.html">Lois Travis, MD, ScD</a>, Lawrence H. Einhorn Professor of Cancer Research</span></figcaption></figure><div class="text"><p><a href="../../../about/members/bio/12422/index.html"><strong>Lois Travis, MD, ScD</strong></a>, oversees work aimed at reducing or eliminating those side effects. Travis is an internationally recognized expert in survivorship and leads the Platinum Study. This global consortium is working to predict who is susceptible to toxicities from cisplatin and protect patients from side effects. Their findings will impact nearly 6 million people treated with platinum-based drugs worldwide.</p><p>The group linked hearing loss in some patients to the total dose of cisplatin they received. Others have a genetic variant that makes them susceptible to neuropathy. This information is invaluable and can help oncologists determine which patients might be most at risk and alter treatments accordingly.</p><p>The insights uncovered through this research will allow survivors to enjoy all life offers—to forge ahead in their careers, watch their children grow, and enjoy intimacy with their partners.</p><p>Travis and her research collaborators published a new study this year that followed a cohort of testicular cancer survivors who received cisplatin-based chemotherapy. Researchers followed the Platinum Study patients for a median of 14 years and found that that 78% experience significant difficulties in everyday listening situations, negatively impacting their quality of life. This collaborative research is the first to measure real-world listening challenges and hearing loss progression in cancer survivors over a long period of time.</p><p>“It will be critically important to follow these patients for life,” Travis said. “Their current median age is only 48 years, and eventually they will enter the years at which age-related hearing loss also begins to develop.”</p></div></div><!-- /.layout --></div></div><div class="bg-none section"><div class="row"><div class="layout"><div class="text"><h3>Honoring John Cleland</h3><p>A 47-year cancer survivor, John Cleland was the first person successfully treated for testicular cancer, thanks to Einhorn’s discovery. He died at age 71 in 2022. <a href="../../focused/john-cleland-fellowship.html"><strong>The John Cleland Fellowship in Testis Cancer Research</strong></a> was established to honor his legacy and encourage ongoing testis cancer research conducted by IU oncology trainees.</p></div><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../../images/people/cleland_einhorn-20231110-768x512.webp"/><figcaption itemprop="caption"><span class="caption-text">John Cleland with Dr. Einhorn</span></figcaption></figure><div class="text"><p>The inaugural Cleland Fellow <strong>Noah Richardson, MD</strong>, immediately got to work to make an impact. Working alongside Dr. Einhorn and others, he authored a study focused on men who had late relapses of their germ cell cancers. Relapses are rare recurrences of testicular cancer more than two years after completion of initial therapy.</p><p>While testicular cancer is highly curable with chemotherapy when first diagnosed—and even in early relapse with further chemotherapy—men whose cancer return in the late relapse period have a low chance of cure with chemotherapy alone. Research showed that surgery continues to be the best treatment option to achieve a cure. Additionally, a simple blood test can identify some late relapses. This study reinforces the critical need for testis cancer survivors to continue annual follow-ups beyond the five-year mark to hopefully detect these relapses earlier when surgery could still be an option for curing these men.</p><p>Now Richardson has signed on to become an IU faculty member following the completion of his fellowship training in August 2025. Your generosity has nurtured this promising young researcher and contributed to his success. Thank you for helping IU retain a brilliant and compassionate physician scientist.</p></div></div><!-- /.layout --></div></div>
</header><main><div class="content-top"><div class="section breadcrumbs"><div class="row"><div class="layout"><ul itemscope="itemscope" itemtype="http://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../../index.html" itemprop="item"><span itemprop="name">Home</span></a><meta content="1" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../index.html" itemprop="item"><span itemprop="name">Patient Info</span></a><meta content="2" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../index.html" itemprop="item"><span itemprop="name">Surviving Cancer</span></a><meta content="3" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="index.html" itemprop="item"><span itemprop="name">The Platinum Study</span></a><meta content="4" itemprop="position"/></li><li class="current" itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><span itemprop="name">Newsletters</span><meta content="5" itemprop="position"/></li></ul></div></div></div><div class="section page-title bg-none"><div class="row"><div class="layout"><h1>Platinum Study Newsletters</h1></div></div></div></div><div id="main-content"><div class="collapsed bg-none section" id="content"><div class="row"><div class="layout"><div class="text"><h2>The latest updates from the Platinum Study</h2><p>The Platinum Study newsletter provides updates on recent research findings, profiles of study investigators and clinicians, participant spotlights, cancer survivorship resources, and more.</p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><div class="text"><h3>Summer 2025</h3><img alt="" class="" height="92" src="../../../images/logos/platinum-study-logo-250x250.png" style="display: inline; float: right; width: 33%; margin-left: 20px; margin-bottom: 20px;" width="93"/><p>In the most recent issue:</p><ul><li>A Platinum Study Update</li><li>Featured Clinician: <span>James C. Root, PhD</span></li><li><span>Clinician's Corner: Cancer-Related Cognitive Dysfunction by Dr. James C. Root, PhD</span></li><li><span>Featured Clinician: Kurt Kroenke, MD</span></li><li><span>Principle Investigator's Corner: Dr. Lois Travis</span></li></ul><p><a href="../../../pdf/platinum-study/platinum_study_newsletter_summer_2025.pdf" rel="noopener" target="_blank">View/download the Summer 2025 Platinum Study Newsletter</a></p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><div class="accordion" data-accordion="" id="accordion-0-1279480799"><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-1" class="accordion-title" id="panel-0-1279480799-1-heading"><span class="accordion-label has-content">Summer 2024</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-1-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-1" role="region"><ul><li>A Platinum Study Update</li><li>Featured Clinician: <span>Dr. M. Eileen Dolan</span></li><li><span>Clinician's Corner: Welcome Dr. Sean Kern!</span></li><li><span>Principle Investigator's Corner: Dr. Lois Travis</span></li></ul><p><a href="../../../pdf/platinum-study/platinum-study-newsletter-11.pdf" rel="noopener" target="_blank">View/download the Summer 2024 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-2" class="accordion-title" id="panel-0-1279480799-2-heading"><span class="accordion-label has-content">Summer 2023</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-2-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-2" role="region"><ul><li>A Platinum Study Update</li><li>Featured Clinician: Victoria Sanchez, MD</li><li>Summary of Publications</li><li>Clinician’s Corner: Happy Birthday Dr. Einhorn</li></ul><p><a href="../../../pdf/platinum-study/platinum-study-newsletter-10.pdf" rel="noopener" target="_blank">View/download the Summer 2023 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-3" class="accordion-title" id="panel-0-1279480799-3-heading"><span class="accordion-label has-content">Summer 2022</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-3-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-3" role="region"><ul><li>John Mark Cleland 1951-2022</li><li>Summary of Publications</li><li>Dr. Travis earns highest honor</li><li>Clinician’s Corner</li></ul><p><a href="../../../pdf/platinum-study/platinum-study-newsletter-9.pdf" rel="noopener" target="_blank">View/download the Summer 2022 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-4" class="accordion-title" id="panel-0-1279480799-4-heading"><span class="accordion-label has-content">Summer 2021</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-4-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-4" role="region"><ul><li>A Platinum Study Update</li><li>Featured Clinician: David J. Vaughn, MD</li><li>Summary of Publications</li><li>Clinician’s Corner: Dr. Einhorn on Hypogonadism</li></ul><p><a href="../../../pdf/platinum_newsletter-summer_2021.pub" rel="noopener" target="_blank">View/download the Summer 2021 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-5" class="accordion-title" id="panel-0-1279480799-5-heading"><span class="accordion-label has-content">Summer 2020</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-5-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-5" role="region"><ul><li>A Platinum Study Update</li><li>New Publication: Journal of Clinical Oncology 2018; 36:1505-1512</li><li>New Publication: J Natl Compr Canc Netw. 2018 Mar;16:257-265</li><li>Featured Clinician: Dr. Chunkit Fung</li></ul><p><a href="../../../pdf/platinum-newsletter-summer-2020.pdf" rel="noopener" target="_blank">View/download the Summer 2020 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-6" class="accordion-title" id="panel-0-1279480799-6-heading"><span class="accordion-label has-content">Winter 2018/2019</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-6-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-6" role="region"><ul><li>A Platinum Study Update</li><li>Featured Clinician: Dr. Sophie Fossa</li><li>New Publication: Clin Cancer Res 2017 Jul 1;23(13):3325-3333</li><li>New Publication: Clin Cancer Res 2017 Oct 1;23 (19):5757-5768</li><li>Featured Study Participant Spotlight: Dr. Greg Steele</li></ul><p><a href="../../../pdf/tps-newsletter-winter-2018-2019.pdf" rel="noopener" target="_blank">View/download the Winter 2018/2019 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-7" class="accordion-title" id="panel-0-1279480799-7-heading"><span class="accordion-label has-content">Winter 2017/2018</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-7-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-7" role="region"><ul><li>A Platinum Study Update</li><li>New Publication: Journal of Clinical Oncology 2017: 35:1211-1222</li><li>New Publication: Journal of Clinical Oncology 2016: 34:2712-2720 (with Editorial)</li><li>Abstracts & Posters: Selected Highlights of Your Data in Action</li><li>What is Tinnitus?</li></ul><p><a href="../../../pdf/platinum-newsletter-winter-2017-2018-nov2017.pdf" rel="noopener" target="_blank">View/download the Winter 2017/2018 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-8" class="accordion-title" id="panel-0-1279480799-8-heading"><span class="accordion-label has-content">Winter/Spring 2017</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-8-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-8" role="region"><ul><li>A Platinum Study Update</li><li>New Publication: Journal of Clinical Oncology, June 2016</li><li>Featured Clinician: Dr. Robert Hamilton</li><li>Investigator Presentations</li><li>2016 Meeting of the American Society of Human Genetics (ASHG)</li><li>Featured Research Study Coordinators: Abigail Blauch, and Donna Pucci, MHK</li></ul><p><a href="../../../pdf/platinum-newsletter-vol-3-issue-1.pdf" rel="noopener" target="_blank">View/download the Winter/Spring 2017 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-9" class="accordion-title" id="panel-0-1279480799-9-heading"><span class="accordion-label has-content">Spring/Summer 2016</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-9-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-9" role="region"><ul><li>A Platinum Study Update</li><li>Featured Clinician: Dr. Darren R. Feldman</li><li>Chemotherapy-Induced Peripheral Neuropathy</li><li>Cancer Survivorship Symposium: Advancing Care and Research</li><li>What is Ototoxicity?</li><li>Featured Health Project Coordinator: Lynn Anson-Cartwright, BSc, CCRA</li></ul><p><a href="../../../pdf/platinum-newsletter-vol2-issue-1-10apr2016.pdf" rel="noopener" target="_blank">View/download the Spring/Summer 2016 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-10" class="accordion-title" id="panel-0-1279480799-10-heading"><span class="accordion-label has-content">Spring/Summer 2015</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-10-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-10" role="region"><ul><li>A Platinum Study update</li><li>Featured Clinician: Dr. Clair Beard</li><li>40th Anniversary Celebration of Einhorn’s Effective Treatment</li><li>Quick Epidemiological Facts About Testicular Cancer</li><li>Emotional Health after Cancer</li><li>A Platinum Study Researcher’s Story: AnnaLynn Williams</li><li>Achieving A Healthy Lifestyle After Cancer</li></ul><p><a href="../../../pdf/platinum-newsletter-vol-1-issue-2-7-2-2015.pdf" rel="noopener" target="_blank">View/download the Spring/Summer 2015 Platinum Study Newsletter</a></p></div><div class="accordion-item"><h2><button aria-controls="panel-0-1279480799-11" class="accordion-title" id="panel-0-1279480799-11-heading"><span class="accordion-label has-content">Summer/Fall 2014</span><span aria-hidden="true" class="accordion-icon"></span></button></h2></div><div aria-labelledby="panel-0-1279480799-11-heading" class="accordion-content" data-tab-content="" id="panel-0-1279480799-11" role="region"><ul><li>About the study</li><li>Core study team</li><li>Featured clinician: Dr. Lawrence Einhorn</li><li>Frequently asked questions with Dr. Einhorn</li><li>What is a gene?</li><li>Chemotherapy-Induced Neuropathy (CIPN): What is it?</li></ul><p><a href="../../../pdf/platinum-newsletter-7-23-2014.pdf" rel="noopener" target="_blank">View/download the Summer/Fall 2014 Platinum Study Newsletter</a></p></div></div></div><!-- /.layout --></div></div>
</header><main><div class="content-top"><div class="section breadcrumbs"><div class="row"><div class="layout"><ul itemscope="itemscope" itemtype="http://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../../index.html" itemprop="item"><span itemprop="name">Home</span></a><meta content="1" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../index.html" itemprop="item"><span itemprop="name">Patient Info</span></a><meta content="2" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../index.html" itemprop="item"><span itemprop="name">Surviving Cancer</span></a><meta content="3" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="index.html" itemprop="item"><span itemprop="name">The Platinum Study</span></a><meta content="4" itemprop="position"/></li><li class="current" itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><span itemprop="name">Research Updates</span><meta content="5" itemprop="position"/></li></ul></div></div></div><div class="section page-title bg-none"><div class="row"><div class="layout"><h1>Research Updates</h1></div></div></div></div><div id="main-content"><div class="collapsed bg-none section" id="content"><div class="row"><div class="layout"><div class="text"><h2>The latest research findings from the Platinum Study</h2><p>The generosity of participants in the Platinum Study is providing new, scientifically important information that is being presented at national and international meetings as well as published in peer-reviewed academic journals.<br/><br/><img alt="" class="" height="92" src="../../../images/logos/platinum-study-logo-250x250.png" style="display: inline; float: right; width: 33%; margin-bottom: 20px; margin-left: 20px;" width="93"/>The initial phases of the study revealed results that investigators are now examining more closely, including:</p><ul><li>The types of hearing loss that may be due to cisplatin-based chemotherapy</li><li>Various health conditions</li><li>Cardiovascular disease risk factors</li><li>The frequency of use of psychotropic medications (antidepressants and stimulants)</li></ul></div></div><!-- /.layout --></div></div><div class="bg-none section"><div class="row"><div class="layout"><div class="text"><h3>Recent publications</h3><p>Kerns SL, Dinh PC, Jr., Monahan PO, Fung C, Sesso HD, Feldman DR, Hamilton RJ, Pierazio P, Huddart R, Kollmannsberger C, Martin NE, Einhorn LH, Travis LB. <a href="https://pubmed.ncbi.nlm.nih.gov/41678227/" rel="noopener" target="_blank">Cardiovascular disease risk among long-term testicular cancer survivors following contemporary cisplatin-based chemotherapy</a>. <u>J Natl Cancer Inst</u>. 2026. Epub 20260212. doi: 10.1093/jnci/djag035. PubMed PMID: 41678227</p><p>Kerns SL, Dinh PC, Jr., Monahan PO, Fung C, Sesso HD, Feldman DR, Hamilton RJ, Vaughn DJ, Kollmannsberger C, Martin NE, Einhorn LH, Travis LB. <a href="https://pubmed.ncbi.nlm.nih.gov/41698327/" rel="noopener" target="_blank">Renal Impairment and Late Toxicities Comparing Contemporary Chemotherapy Regimens for Testicular Cancer in a Real-World Setting</a>. <u>J Natl Compr Canc Netw</u>. 2026:1-10. Epub 20260213. doi: 10.6004/jnccn.2025.7120. PubMed PMID: 41698327.</p><p>Nakshatri S, Dinh PC, Jr., Einhorn LH, Feldman DR, Hamilton RJ, Vaughn DJ, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/40913328/">Impact of Population Pharmacogenomics on Cisplatin-Induced Neurotoxicities in Testicular Cancer Survivors</a>. Cancer Med. 2025 Sep;14(17):e71218. doi: 10.1002/cam4.71218. PMID: 40913328; PMCID: PMC12413486.</p><ul><li><a href="../../../documents/platinum/psnvertigogenotypephenotypeassociationanalysis.xlsx">Genotype–phenotype Association Analysis Summary Statistics for Cisplatin‐induced Peripheral Sensory Neuropathy and Vertigo</a></li></ul><p><span>Kerns SL, Dinh PC Jr, Monahan PO, Stump T, Fung C, Sesso HD, Feldman DR, Hamilton RJ, Vaughn DJ, Huddart R, Kollmannsberger C, Martin NE, Nevel K, Kincaid J, Einhorn LH, Travis LB. <a href="https://pubmed.ncbi.nlm.nih.gov/39898813/" rel="noopener" target="_blank">Factors associated with longitudinal progression of the cumulative burden of morbidity and overall mortality after cisplatin-based chemotherapy for testicular cancer</a>. J Natl Cancer Inst. 2025 Feb 3:djaf014. doi: 10.1093/jnci/djaf014. Epub ahead of print. PMID: 39898813.</span></p><p>Dinh PC, Jr., Monahan PO, Fung C, Sesso HD, Feldman DR, Vaughn DJ, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/39141447/" rel="noopener" target="_blank">Cognitive function in long-term testicular cancer survivors: impact of modifiable factors</a>. JNCI Cancer Spectr. 2024 Sep 2;8(5). doi: 10.1093/jncics/pkae068. PMID: 39141447; PMCID: PMC11424079.</p><p>Sanchez VA, Dinh PC, Jr., Monahan PO, Althouse S, Rooker J, Sesso HD, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/38842797/" rel="noopener" target="_blank">Comprehensive Audiologic Analyses After Cisplatin-Based Chemotherapy</a>. JAMA Oncol. 2024 Jul 1;10(7):912-22. doi: 10.1001/jamaoncol.2024.1233. PMID: 38842797; PMCID: PMC11157440.</p><p>Travis LB, Feldman DR, Fung C, Poynter JN, Lockley M, Frazier AL. <a href="https://pubmed.ncbi.nlm.nih.gov/37820296/" rel="noopener" target="_blank">Adolescent and Young Adult Germ Cell Tumors: Epidemiology, Genomics, Treatment, and Survivorship</a>. J Clin Oncol. 2024;42(6):696-706. Epub 20231011. doi: 10.1200/jco.23.01099. PubMed PMID: 37820296.</p><p>Dinh PC, Jr., Monahan PO, Fossa SD, Sesso HD, Feldman DR, Dolan ME, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/37966940/" rel="noopener" target="_blank">Impact of pain and adverse health outcomes on long-term US testicular cancer survivors</a>. J Natl Cancer Inst. 2024 Mar 7;116(3):455-67. Epub 20231115. doi: 10.1093/jnci/djad236. PMID: 37966940.</p><p>Clasen SC, Fung C, Sesso HD, Travis LB. <a href="https://pubmed.ncbi.nlm.nih.gov/36867377/" rel="noopener" target="_blank">Cardiovascular Risks in Testicular Cancer: Assessment, Prevention, and Treatment</a>. Curr Oncol Rep. 2023 May;25(5):445-54. Epub 20230303. doi: 10.1007/s11912-023-01375-8. PMID: 36867377.</p><p>Sanchez VA, Shuey MM, Dinh PC, Jr., Monahan PO, Fossa SD, Sesso HD, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/36626694/" rel="noopener" target="_blank">Patient-Reported Functional Impairment Due to Hearing Loss and Tinnitus After Cisplatin-Based Chemotherapy</a>. J Clin Oncol. 2023 Apr 20;41(12):2211-26. Epub 20230110. doi: 10.1200/JCO.22.01456. PMID: 36626694; PMCID: PMC10489421.</p><p>Sanchez VA, Dinh PC, Jr., Rooker J, Monahan PO, Althouse SK, Fung C, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/36637632/" rel="noopener" target="_blank">Prevalence and risk factors for ototoxicity after cisplatin-based chemotherapy</a>. J Cancer Surviv. 2023 Feb;17(1):27-39. Epub 20230113. doi: 10.1007/s11764-022-01313-w. PMID: 36637632.</p><p>Shahbazi M, Zhang X, Dinh PC, Sanchez VA, Trendowski MR, Shuey MM, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/36097363/" rel="noopener" target="_blank">Comprehensive association analysis of speech recognition thresholds after cisplatin-based chemotherapy in survivors of adult-onset cancer</a>. Cancer Med. 2023 Feb;12(3):2999-3012. Epub 20220912. doi: 10.1002/cam4.5218. PMID: 36097363; PMCID: PMC9939144.</p><ul><li><a class="external" href="https://indiana-my.sharepoint.com/:u:/g/personal/iuccit_iu_edu/ESpkM76FQkFAgl5zBqiWCMYBTN4PnnXv-q8miP5YH6w6zA?e=xbGC4l" rel="noopener" target="_blank">GWAS Summary Statistics of Speech Recognition Threshold in Testicular Cancer Survivors</a></li></ul><p>Zhang X, Trendowski MR, Wilkinson E, Shahbazi M, Dinh PC, Shuey MM, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/35322580/" rel="noopener" target="_blank">Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy</a>. Cancer Med. 2022 Jul;11(14):2801-16. Epub 20220323. doi: 10.1002/cam4.4644. PMID: 35322580; PMCID: PMC9302309.</p><ul><li><a class="external" href="https://indiana-my.sharepoint.com/:u:/g/personal/janichol_iu_edu/EXzMjoJy-q5Hnputo5mwx4UBQ1n_iQUh62fFtYphpts-ww?e=wbqfus" rel="noopener" target="_blank">GWAS Summary Statistics of Cisplatin-induced Hearing Loss</a></li><li><a class="external" href="https://indiana-my.sharepoint.com/:u:/g/personal/janichol_iu_edu/ERtqyeaLxOxBmT4miRzcCY4BWfAfR31LPNeT-otjVgl8qg?e=EdkSrr" rel="noopener" target="_blank">GWAS Summary Statistics of Cisplatin-induced Tinnitus</a></li><li><a class="external" href="https://indiana-my.sharepoint.com/:u:/g/personal/janichol_iu_edu/ES0XzLkchI5Kp0dzg-ys9WUBD9Xdtb9dNkfedRpFLscqUQ?e=ZOVgSm" rel="noopener" target="_blank">GWAS Summary Statistics of Cisplatin-induced Peripheral Neuropathy</a></li></ul><p>Wibmer AG, Dinh PC, Travis LB, Chen C, Bromberg M, Zheng J, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/35801305/" rel="noopener" target="_blank">Associations of Body Fat Distribution and Cardiometabolic Risk of Testicular Cancer Survivors After Cisplatin-Based Chemotherapy</a>. JNCI Cancer Spectr. 2022 Jul 1;6(4). doi: 10.1093/jncics/pkac030. PMID: 35801305; PMCID: PMC9263534.</p><p>Ardeshirrouhanifard S, Fossa SD, Huddart R, Monahan PO, Fung C, Song Y, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/35067571/" rel="noopener" target="_blank">Ototoxicity After Cisplatin-Based Chemotherapy: Factors Associated With Discrepancies Between Patient-Reported Outcomes and Audiometric Assessments</a>. Ear Hear. 2022 May/Jun;43(3):794-807. Epub 20220121. doi: 10.1097/AUD.0000000000001172. PMID: 35067571; PMCID: PMC9010341.</p><p>Fung C, Dinh PC, Jr., Travis LB. <a href="https://pubmed.ncbi.nlm.nih.gov/35000551/" rel="noopener" target="_blank">Re: Thyroid hypofunction in aging testicular cancer survivors</a>. Acta Oncol. 2022 Mar;61(3):386-7. Epub 20220110. doi: 10.1080/0284186X.2021.2024880. PMID: 35000551; PMCID: PMC9875322.</p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><div class="text"><h3>Recent presentations</h3><p>In 2024, Dr. Travis presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago:</p><p><a href="../../../images/lois-b-travis-asco-slides-final.pptx" rel="noopener" target="_blank">Long-term Survivorship in Testicular Cancer.</a></p><p>In June 2022, we presented six abstracts at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago:</p><p>Nakshatri S, Shuey M, Shahbazi M, Trendowski M, Dinh P, Feldman D, Hamilton R, Vaughn D, Fung C, Kollmansberger C, Einhorn L, Frisina R, <strong>Travis LB</strong>, Dolan E, Cox N.  Building a model to predict the risk of multiple severe neurotoxicities in cancer survivors after cisplatin treatment. Presented at  ASCO 2022 Annual Meeting, Chicago, IL.  <u>J Clin Oncol 40, 2022 (suppl 16, abstr e24066. </u> DOI: 10.1200/JCO.2022.40.16_suppl.e24066</p><p>Dinh P, Monahan P, Clasen S, Sesso H, Einhorn L, Fossa S, Vaughn D, Martin N, Fung C, <strong>Travis LB</strong>.  Impact of Adverse Health Outcomes on Self-Reported Physical and Mental Health in U.S. Testicular Cancer Survivors. Presented at ASCO 2022 Annual Meeting, Chicago, IL. <u> J Clin Oncol 40, 2022 (suppl 16; abstr 12080</u>.  DOI: 10.1200/JCO.2022.40.16_suppl. 12080</p><p>Sanchez V, Shuey M, Dinh P, Monahan P, Sesso H, Dolan E, Einhorn L, Vaughn D, Martin N, Fung C, Frisina R, <strong>Travis LB</strong>.  Impact of Cisplatin-induced Hearing Loss  on Patient-Reported Social and Emotional Functioning. Presented at ASCO 2022 Annual Meeting, Chicago IL.  <u>J Clin Oncol 40, 2022 (suppl 16; abstr 12120)</u>.  DOI:  10.1200/JCO.2022.40.16_suppl. 12120</p><p>Shuey M, Sanchez V, Dinh P, Monahan P, Sesso H, Dolan E, Einhorn L, Vaughn D, Martin N, Fung C, Frisina R, <strong>Travis LB</strong>.  Cisplatin-induced Tinnitus and Patient-Reported Outcomes in Adult-Onset Cancer Survivors. Presented at ASCO 2022 Annual Meeting, Chicago, IL.  <u>J Clin Oncol 40, 2022 (suppl 16; abstr e24089).</u>  DOI:  10.1200<u>/JCO.2022.40.16_suppl.e24089</u></p><p>Zheng Y, Wang J, Dinh P, Nathanson K, Weathers B, Jacobs L, Vaughn D, Hou L, <strong>Travis LB</strong>.  Epigenetic Age Acceleration in  U.S. Testicular Cancer Survivors. Presented at ASCO 2022 Annual Meeting, Chicago, IL.  <u>J Clin Oncol 40, 2022.  Suppl 16; abstr 5033</u>  DOI:  10.1200/JCO.2022.40.16_suppl. 5033</p><p>Miller M, Ashkar R, Althouse S, Hanna N, Abonour R, <strong>Travis LB</strong>, Einhorn L, Adra N, Abu Zaid M.  Adverse health outcomes  in testis cancer survivors following high dose chemotherapy  and autologous stem cell transplant. Presented at ASCO 2022 Annual Meeting, Chicago, IL.  <u>J Clin Oncol 40, 2022 (suppl 16; abstr 12083)</u>.  DOI: 10.1200/JCO.2022.40.16_suppl. 12083 </p></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><h3 class="section-title">More publications</h3><div class="accordion" data-accordion="" id="accordion-0-881890622"><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-1" class="accordion-title" id="panel-0-881890622-1-heading"><span class="accordion-label has-content">2021</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-1-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-1" role="region"><p>Ardeshirrouhanifard S,et al. <a href="https://pubmed.ncbi.nlm.nih.gov/33849970/">Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study</a>. Cancer Epidemiol Biomarkers Prev. 2021 Jun;30(6):1129-1138. doi: 10.1158/1055-9965.EPI-20-1762. Epub 2021 Apr 13. PMID: 33849970; PMCID: PMC8172470. </p><p>Trendowski MR, Baedke J, Sapkota Y, El Charif O, Wheeler HE, Leisenring W, Robison LL, Hudson MM, Morton L, Oeffinger KC, <strong>Travis LB</strong>, Howell RM, Yasui Y, Armstrong GT, Bhatia S, Dolan ME.  Clinical and Genetic Risk Factors for Radiation-Associated Ototoxicity: A Report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.  <u>Cancer</u>.  2021 Jul 19,  PMID: 3428686 <span>doi: 10.1002/cncr.33775.</span> </p><p>Fung C, Travis LB. <a href="https://pubmed.ncbi.nlm.nih.gov/34591594/">(Editorial) Testicular Cancer Survivorship: Looking Back to Move Forward</a>. J Clin Oncol. 2021 Nov 10;39(32):3531-3534. doi: 10.1200/JCO.21.01984. Epub 2021 Sep 30. PMID: 34591594; PMCID: PMC8577670.</p><p>Clasen SC, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/34629110/">Cisplatin, environmental metals, and cardiovascular disease: an urgent need to understand underlying mechanisms. Cardiooncology</a>. 2021 Oct 10;7(1):34. doi: 10.1186/s40959-021-00120-z. PMID: 34629110; PMCID: PMC8504106.</p></div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-2" class="accordion-title" id="panel-0-881890622-2-heading"><span class="accordion-label has-content">2020</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-2-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-2" role="region">Kerns SL, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/32704617/" rel="noopener" target="_blank">Relationship of Cisplatin-Related Adverse Health Outcomes With Disability and Unemployment Among Testicular Cancer Survivors</a>. JNCI Cancer Spectr. 2020 Mar 20;4(4):pkaa022. doi: 10.1093/jncics/pkaa022. PMID: 32704617; PMCID: PMC7368467.</div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-3" class="accordion-title" id="panel-0-881890622-3-heading"><span class="accordion-label has-content">2019</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-3-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-3" role="region"><p>Agrawal V, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/32190815/" rel="noopener" target="_blank">Adverse Health Outcomes Among US Testicular Cancer Survivors After Cisplatin-Based Chemotherapy vs Surgical Management</a>. JNCI Cancer Spectr. 2019 Oct 8;4(2):pkz079. doi: 10.1093/jncics/pkz079. PMID: 32190815; PMCID: PMC7065712.<br/><br/>El Charif O, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/30952644/" rel="noopener" target="_blank">Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms</a>. Clin Cancer Res. 2019 Jul 1;25(13):4104-4116. doi: 10.1158/1078-0432.CCR-18-3179. Epub 2019 Apr 5. PMID: 30952644; PMCID: PMC6903403.<br/><br/>Nichols CR, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/32190816/" rel="noopener" target="_blank">Back to the Future-Moving Forward for Testicular Cancer Survivors</a>. JNCI Cancer Spectr. 2019 Oct 8;4(2):pkz082. doi: 10.1093/jncics/pkz082. PMID: 32190816; PMCID: PMC7065711.<br/><br/>Trendowski MR, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/31296530/" rel="noopener" target="_blank">Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy</a>. Clin Cancer Res. 2019 Oct 1;25(19):5913-5924. doi: 10.1158/1078-0432.CCR-19-0113. Epub 2019 Jul 11. PMID: 31296530; PMCID: PMC6774840.<br/><br/>Abu Zaid M, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/31085753/" rel="noopener" target="_blank">Adverse Health Outcomes in Relationship to Hypogonadism After Chemotherapy: A Multicenter Study of Testicular Cancer Survivors</a>. J Natl Compr Canc Netw. 2019 May 1;17(5):459-468. doi: 10.6004/jnccn.2018.7109. PMID: 31085753; PMCID: PMC6712564.<br/><br/>Trendowski MR, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/30305294/" rel="noopener" target="_blank">Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities</a>. Clin Cancer Res. 2019 Feb 15;25(4):1147-1155. doi: 10.1158/1078-0432.CCR-18-2244. Epub 2018 Oct 10. PMID: 30305294; PMCID: PMC6377815.</p></div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-4" class="accordion-title" id="panel-0-881890622-4-heading"><span class="accordion-label has-content">2018</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-4-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-4" role="region"><p>Zaid MA, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/29523664/" rel="noopener" target="_blank">Clinical and Genetic Risk Factors for Adverse Metabolic Outcomes in North American Testicular Cancer Survivors</a>. J Natl Compr Canc Netw. 2018 Mar;16(3):257-265. doi: 10.6004/jnccn.2017.7046. PMID: 29523664; PMCID: PMC6345519.</p><p>Fung C, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/29670654/" rel="noopener" target="_blank">Toxicities Associated with Cisplatin-Based Chemotherapy and Radiotherapy in Long-Term Testicular Cancer Survivors</a>. Adv Urol. 2018 Feb 18;2018:8671832. doi: 10.1155/2018/8671832. PMID: 29670654; PMCID: PMC5835297.</p><p>Kerns SL, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/29617189/" rel="noopener" target="_blank">Cumulative Burden of Morbidity Among Testicular Cancer Survivors After Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study</a>. J Clin Oncol. 2018 May 20;36(15):1505-1512. doi: 10.1200/JCO.2017.77.0735. Epub 2018 Apr 4. PMID: 29617189; PMCID: PMC5959198.</p><p>Feldman DR, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/29534941/" rel="noopener" target="_blank">Predicting Cardiovascular Disease Among Testicular Cancer Survivors After Modern Cisplatin-based Chemotherapy: Application of the Framingham Risk Score</a>. Clin Genitourin Cancer. 2018 Aug;16(4):e761-e769. doi: 10.1016/j.clgc.2018.01.011. Epub 2018 Feb 5. PMID: 29534941; PMCID: PMC6063791.</p></div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-5" class="accordion-title" id="panel-0-881890622-5-heading"><span class="accordion-label has-content">2017</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-5-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-5" role="region"><p>Wheeler HE, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/28039263/" rel="noopener" target="_blank">Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity</a>. Clin Cancer Res. 2017 Jul 1;23(13):3325-3333. doi: 10.1158/1078-0432.CCR-16-2809. Epub 2016 Dec 30. PMID: 28039263; PMCID: PMC5493516.<br/><br/>Dolan ME, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/28611204/" rel="noopener" target="_blank">Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer</a>. Clin Cancer Res. 2017 Oct 1;23(19):5757-5768. doi: 10.1158/1078-0432.CCR-16-3224. Epub 2017 Jun 13. PMID: 28611204; PMCID: PMC5626588.<br/><br/>Fung C, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/28240972/" rel="noopener" target="_blank">Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy</a>. J Clin Oncol. 2017 Apr 10;35(11):1211-1222. doi: 10.1200/JCO.2016.70.3108. Epub 2017 Feb 27. PMID: 28240972; PMCID: PMC5455601.<br/><br/>Wheeler HE, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/28039263/" rel="noopener" target="_blank">Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity</a>. Clin Cancer Res. 2017 Jul 1;23(13):3325-3333. doi: 10.1158/1078-0432.CCR-16-2809. Epub 2016 Dec 30. PMID: 28039263; PMCID: PMC5493516.</p></div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-6" class="accordion-title" id="panel-0-881890622-6-heading"><span class="accordion-label has-content">2016</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-6-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-6" role="region"><p>Frisina RD, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/27354478/" rel="noopener" target="_blank">Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer</a>. J Clin Oncol. 2016 Aug 10;34(23):2712-20. doi: 10.1200/JCO.2016.66.8822. Epub 2016 Jun 27. PMID: 27354478; PMCID: PMC5019759.<br/><br/>Oldenburg J, Gietema JA. <a href="https://pubmed.ncbi.nlm.nih.gov/27382103/" rel="noopener" target="_blank">EDITORIAL: The Sound of Silence: A Proxy for Platinum Toxicity</a>. J Clin Oncol. 2016 Aug 10;34(23):2687-9. doi: 10.1200/JCO.2016.68.2476. Epub 2016 Jul 5. PMID: 27382103; PMCID: PMC5019766.<br/><br/>Strathmann FG, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/33626787/" rel="noopener" target="_blank">Residual Platinum Concentrations in Post-Cancer Chemotherapy and Healthy Control Populations Using an Automated, 96-Well Plate Method and Inductively Coupled Plasma Mass Spectrometry</a>. J Appl Lab Med. 2016 Sep 1;1(2):143-151. doi: 10.1373/jalm.2016.020081. PMID: 33626787.</p></div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-7" class="accordion-title" id="panel-0-881890622-7-heading"><span class="accordion-label has-content">2015</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-7-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-7" role="region"><p>Brewer JR, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/26556766/" rel="noopener" target="_blank">Chemotherapy-induced peripheral neuropathy: Current status and progress</a>. Gynecol Oncol. 2016 Jan;140(1):176-83. doi: 10.1016/j.ygyno.2015.11.011. Epub 2015 Nov 7. PMID: 26556766; PMCID: PMC4698212.<br/><br/>Fung C, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/26240226/" rel="noopener" target="_blank">Cardiovascular Disease Mortality After Chemotherapy or Surgery for Testicular Nonseminoma: A Population-Based Study</a>. J Clin Oncol. 2015 Oct 1;33(28):3105-15. doi: 10.1200/JCO.2014.60.3654. Epub 2015 Aug 3. PMID: 26240226; PMCID: PMC4582143.<br/><br/>Wheeler HE, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/25689802/" rel="noopener" target="_blank">Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells</a>. PLoS One. 2015 Feb 17;10(2):e0118020. doi: 10.1371/journal.pone.0118020. PMID: 25689802; PMCID: PMC4331516.</p></div><div class="accordion-item"><h4><button aria-controls="panel-0-881890622-8" class="accordion-title" id="panel-0-881890622-8-heading"><span class="accordion-label has-content">2014</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-0-881890622-8-heading" class="accordion-content" data-tab-content="" id="panel-0-881890622-8" role="region">Travis LB, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/24623533/" rel="noopener" target="_blank">Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics</a>. J Natl Cancer Inst. 2014 Mar 12;106(5):dju044. doi: 10.1093/jnci/dju044. PMID: 24623533; PMCID: PMC4568989.</div></div></div><!-- /.layout --></div></div><div class="collapsed bg-none section"><div class="row"><div class="layout"><h3 class="section-title">More presentations</h3><div class="accordion" data-accordion="" id="accordion-1-881890622"><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-1" class="accordion-title" id="panel-1-881890622-1-heading"><span class="accordion-label has-content">2021</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-1-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-1" role="region"><p>In June 2021, we presented five abstracts at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago:</p><p>Shuey, et al. <a href="https://meetings.asco.org/abstracts-presentations/200638" rel="noopener" target="_blank">Integration of a polygenic risk score of kidney function with cumulative cisplatin dose and time variables for the prediction of serum platinum levels</a>.J Clin Oncol 39, 2021 (suppl 15; abstr 12063). doi:J Clin Oncol 39, 2021 (suppl 15; abstr 12063).<br/><br/> Zhang, et al. <a href="https://meetings.asco.org/abstracts-presentations/197896" rel="noopener" target="_blank">Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus and peripheral sensory neuropathy</a>. J Clin Oncol 39, 2021 (suppl 15; abstr 12004). doi:10.1200/JCO.2021.39.15_suppl.12004.</p><p>Ardeshirrouhanifard, et al. <a href="https://meetings.asco.org/abstracts-presentations/195683" rel="noopener" target="_blank">Hearing Loss after Cisplatin-based Chemotherapy: Patient-reported Outcomes versus Audiometric Assessments</a>. J Clin Oncol 39, 2021 (suppl 15; abstr 5016). doi:10.1200/JCO.2021.39.15_suppl.5016.<br/><br/> Ardeshirrouhanifard, et al. <a href="https://meetings.asco.org/abstracts-presentations/197752" rel="noopener" target="_blank">Factors associated with use of medications for anxiety and depression in testicular cancer survivors after cisplatin-based chemotherapy</a>. J Clin Oncol 39, 2021 (suppl 15; abstr 5025). doi:10.1200/JCO.2021.39.15_suppl.5025.</p><p>Wibmer AG, Feldman DR, Chen C, Bromberg M, Dinh PC, Zheng J, Capanu M, <strong>Travis LB,</strong> Vargas HA. Effect of pretreatment central adiposity on the cardiometabolic risk of male germ cell tumor survivors after cisplatin-based chemotherapy. Journal of Clinical Oncology. 2021;39(15_suppl):5019-. doi: 10.1200/JCO.2021.39.15_suppl.5019.</p></div><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-2" class="accordion-title" id="panel-1-881890622-2-heading"><span class="accordion-label has-content">2020</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-2-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-2" role="region"><p>Zhang X, Trendowski MR, Wilkinson E, Wheeler HE, El-Charif O, Dinh P, Feldman DR, Hamilton RJ, Vaughn DJ, Fung C, Kollmannsberger C, Einhorn LH, <strong>Travis, LB</strong>, Dolan ME.  Pharmacogenomics of Cisplatin-Induced Toxicities: Peripheral Neuropathy, Hearing Loss and Tinnitus.  Presented at the Pharmacogenetics Research Network, October 26, 2020.</p><p>Trendowski MR, Baedke J, Sapkota Y, El Charif O, Wheeler HE, Leisenring W, Robison LL, Hudson MM, Morton L, Oeffinger KC, <strong>Travis LB</strong>, Howell RM, Yasui Y, Armstrong GT, Bhatia S, Dolan ME.  Clinical and Genetic Risk Factors for Radiation-Associated Ototoxicity: A Report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.  <u>Journal of Clinical Oncology</u>.  38, 2020 (suppl; abstr e10550)</p></div><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-3" class="accordion-title" id="panel-1-881890622-3-heading"><span class="accordion-label has-content">2019</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-3-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-3" role="region"><p><strong>June 2019</strong>: Two abstracts presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago:</p><ul><li><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.e16058?af=R" rel="noopener" target="_blank">Impact of Cisplatin-Related Adverse Health Outcomes on Disability, Unemployment and Self-Reported Health Among Testicular Cancer Survivors</a></li><li><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.e23085" rel="noopener" target="_blank">Impact of Cisplatin-related Hearing Loss and Tinnitus on Patient Functioning</a></li></ul><p><br/><strong>April 2019</strong>: One abstract was presented at the AACR annual meeting in Atlanta:</p><ul><li><a href="https://aacrjournals.org/cancerres/article/79/13_Supplement/3904/635815/Abstract-3904-Pharmacokinetic-modeling-of-serum" rel="noopener" target="_blank">Pharmacokinetic modeling of serum platinum reveals extent of long-term exposure and associated comorbidities after cisplatin treatment</a></li></ul></div><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-4" class="accordion-title" id="panel-1-881890622-4-heading"><span class="accordion-label has-content">2018</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-4-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-4" role="region"><p><strong>June 2018</strong>: One abstract presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago:</p><ul><li><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e22068" rel="noopener" target="_blank">Adverse Health Outcomes After Modern Cisplatin-Based Chemotherapy Compared to Surgery-Only: A Study of 503 Testicular Cancer Survivors</a></li></ul></div><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-5" class="accordion-title" id="panel-1-881890622-5-heading"><span class="accordion-label has-content">2017</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-5-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-5" role="region"><p><strong>October 2017</strong>: Two abstracts presented at the annual meeting of the American Society of Human Genetics in Orlando:</p><ul><li><a href="../../../pdf/platinum-study/pgmnr_648_mapes_gwas_of_ci_tinnitus.pdf" rel="noopener" target="_blank">A genome-wide association study of cisplatin-induced tinnitus in adult cancer survivors</a> (PDF)</li><li><a href="../../../pdf/platinum-study/pgmnr_2042_el_charif_polygenic_analysis_of_persistent_cipn_implicate_immune.pdf" rel="noopener" target="_blank">Polygenic Analysis of Persistent Cisplatin-Induced Peripheral Neuropathy Implicates Immune-Mediated Processes</a> (PDF)</li></ul><p><strong>June 2017</strong>: Three abstracts presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago:</p><ul><li><a href="https://meetings.asco.org/abstracts-presentations/147393" rel="noopener" target="_blank">Adverse health outcomes in relationship to serum testosterone levels after platinum-based chemotherapy (CHEM): a multi-center study of North American testicular cancer survivors (TCS)</a>.This was a Platform Presentation & Late Breaking Abstract/Poster Discussion Session selected for ASCO’s official press program (Top 1%).</li><li><a href="https://meetings.asco.org/abstracts-presentations/152216" rel="noopener" target="_blank">Genome-wide association study (GWAS) of chemotherapy-induced Raynaud’s phenomenon (RP) to reveal shared pathways with cardiovascular disease (CVD)</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/150354" rel="noopener" target="_blank">Clinical, sociodemographic, and behavioral factors associated with cumulative burden of morbidity (CBM) among testicular cancer survivors (TCS) in the Platinum study</a></li></ul><p><br/><strong>January 2017</strong>: One abstract presented at the ASCO Cancer Survivorship Symposium, in San Diego:</p><ul><li><a href="https://meetings.asco.org/abstracts-presentations/139946" rel="noopener" target="_blank">Metabolic syndrome (MetS) after platinum-based chemotherapy (CHEM): A multicenter study of North American testicular cancer survivors (TCS)</a></li></ul></div><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-6" class="accordion-title" id="panel-1-881890622-6-heading"><span class="accordion-label has-content">2016</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-6-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-6" role="region"><p><strong>October 2016</strong>: Two abstracts submitted and presented at the annual meeting of the American Society of Human Genetics 66th Annual Meeting in Vancouver, with one of our young investigators receiving a Reviewers’ Choice Award:</p><ul><li><a href="https://www.ashg.org/wp-content/uploads/2019/10/2016-plenary_platform_abstracts.pdf" rel="noopener" target="_blank">Genome-wide association study with replication implicates WFS1 in cisplatin-associated hearing loss and reveals an enrichment of SNPs in Mendelian genes for deafness</a></li><li><a href="https://www.ashg.org/wp-content/uploads/2019/10/2016-poster-abstracts.pdf" rel="noopener" target="_blank">Genome-wide association study of cisplatin-induced peripheral neuropathy (CIPN) in testicular cancer survivors</a></li></ul><p><br/><strong>June 2016</strong>: Six abstracts submitted and presented at the annual meeting of the American Society of Clinical Oncology, with one of our young investigators receiving a Merit Award:</p><ul><li><a href="https://meetings.asco.org/abstracts-presentations/123966" rel="noopener" target="_blank">Genome-wide association study (GWAS) of cisplatin-related hearing loss in testicular cancer survivors (TCS) to reveal associated variant in Wolfram syndrome 1 (WFS1) gene</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/126653" rel="noopener" target="_blank">Estimation of 10-year (y) cardiovascular disease (CVD) risk after cisplatin-based chemotherapy (CBCT): A multi-institutional study of 459 germ cell tumor (GCT) survivors in the Platinum study.</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/122739" rel="noopener" target="_blank">Genome-wide association study of cisplatin-induced peripheral neuropathy (CIPN) in testicular cancer survivors</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/125585" rel="noopener" target="_blank">Variation in protein-coding sequence and the genetic basis of cisplatin-induced toxicities among testicular cancer survivors (TCS) in the Platinum Study</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/126606" rel="noopener" target="_blank">*Cardiovascular disease (CVD) risk factors and health behaviors after cisplatin-based chemotherapy (CHEM): A multi-institutional study of testicular cancer survivors (TCS) in the Platinum study</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/126615" rel="noopener" target="_blank">Cumulative burden of morbidity (CBM) among testicular cancer survivors (TCS) in the Platinum study</a></li></ul><p><br/><strong>January 2016</strong>: Three abstracts submitted and accepted for presentation at the ASCO Cancer Survivorship Symposium in San Francisco, with one of our young investigators receiving a Merit Award. One of the abstracts was also selected for oral presentation at the opening of the session:</p><ul><li><a href="https://meetings.asco.org/abstracts-presentations/120038" rel="noopener" target="_blank">Cumulative Burden of Morbidity (CBM) among Testicular Cancer Survivors (TCS) in the Platinum Study</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/119160" rel="noopener" target="_blank">Cardiovascular disease (CVD) risk factors and health behaviors following cisplatin-based chemotherapy (CHEM): a multi-institutional study of testicular cancer survivors (TCS)</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/119223" rel="noopener" target="_blank">Psychotropic and stimulant medication (PSM) use among testicular cancer survivors (TCS): A multi-institutional clinical study of 680 patients given cisplatin-based chemotherapy (CHEM) (NCI 1R01 CA157823-02)</a></li></ul></div><div class="accordion-item"><h4><button aria-controls="panel-1-881890622-7" class="accordion-title" id="panel-1-881890622-7-heading"><span class="accordion-label has-content">2015</span><span aria-hidden="true" class="accordion-icon"></span></button></h4></div><div aria-labelledby="panel-1-881890622-7-heading" class="accordion-content" data-tab-content="" id="panel-1-881890622-7" role="region"><p><strong>June 2015</strong>: One abstract presented at the Multinational Association of Supportive Care in Cancer (MASCC) in Copenhagen, Denmark:</p><ul><li><a href="https://cancer.iu.edu/pdf/platinum-study/mascc_abstract_02-13-2015.pdf" rel="noopener" target="_blank">Psychotropic and stimulant medication (PSM) use among testicular cancer survivors (TCS): A multi-institutional clinical study of 680 patients given cisplatin-based chemotherapy (CHEM) (NCI 1R01 CA157823-02)</a> (PDF)</li></ul><p><br/><strong>May 2015</strong>: Two abstracts presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, with one of the abstracts receiving a Young Investigator Travel Award:</p><ul><li><a href="https://meetings.asco.org/abstracts-presentations/113076/video" rel="noopener" target="_blank">Chronic health conditions following cisplatin-based chemotherapy: a multi-institutional study of 680 testicular cancer survivors (TCS)</a></li><li><a href="https://meetings.asco.org/abstracts-presentations/113075" rel="noopener" target="_blank">Comprehensive characterization of cisplatin-related hearing loss in U.S. and Canadian testicular cancer survivors (TCS)</a></li></ul><p><strong>February 2015</strong>: One abstract presented at the Genitourinary Cancer Symposium of the American Society of Clinical Oncology (GU ASCO).</p><ul><li><a href="https://ascopubs.org/doi/abs/10.1200/jco.2015.33.7_suppl.391" rel="noopener" target="_blank">Cardiovascular disease (CVD) risk factors among cisplatin-treated testicular cancer survivors (TCS): A multicenter study of U.S. and Canadian Patients</a></li></ul></div></div></div><!-- /.layout --></div></div>
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June 21
</header><main><div class="content-top"><div class="section breadcrumbs"><div class="row"><div class="layout"><ul itemscope="itemscope" itemtype="http://schema.org/BreadcrumbList"><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../../index.html" itemprop="item"><span itemprop="name">Home</span></a><meta content="1" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="../index.html" itemprop="item"><span itemprop="name">Giving</span></a><meta content="2" itemprop="position"/></li><li itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><a href="index.html" itemprop="item"><span itemprop="name">Focused Giving</span></a><meta content="3" itemprop="position"/></li><li class="current" itemprop="itemListElement" itemscope="itemscope" itemtype="http://schema.org/ListItem"><span itemprop="name">Jeanne & Martha</span><meta content="4" itemprop="position"/></li></ul></div></div></div><div class="section page-title bg-none"><div class="row"><div class="layout"><h1>Jeanne & Martha</h1></div></div></div></div><div id="main-content"><div class="bg-none section" id="content"><div class="row"><div class="layout"><h2 class="section-title">Jeanne & Martha Fore A Cure Fund for Cancer Research</h2><div class="text"><p>The IU Simon Comprehensive Cancer Center is the grateful recipient of gifts honoring Jeanne Potts and Martha Sullivan through the<strong> Jeanne & Martha Fore A Cure Fund for Cancer Research</strong>.<strong> </strong></p><p><a class="button" href="https://give.myiu.org/crowdfunding/I380015965-CF.html" rel="noopener" target="_blank">Give Now</a></p></div><div class="float-left one-half"><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/jeanne-martha-focused-giving1-370x370.jpg"/><figcaption itemprop="caption"><span class="caption-text">Steven & Martha</span></figcaption></figure></div><div class="float-right one-half"><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/jeanne-martha-focused-giving-370x370.jpg"/><figcaption itemprop="caption"><span class="caption-text">Jeanne & Jake</span></figcaption></figure></div></div><!-- /.layout --><div class="layout"><div class="text"><p>Martha Sullivan is a survivor of acute myeloma leukemia and Jeanne Potts lost her battle with metastatic breast cancer on June 21, 2021. In gratitude for the research that led to the therapies that their mothers received and to continue to honor these courageous women, their sons Steven Sullivan and Jake Peacock partnered together to establish the Jeanne & Martha Fore A Cure Fund. Your gift to this fund will support the work of nearly 300 researchers who investigate everything from understanding the molecular changes that cause cancer to the development of targeted therapies to prevent and treat cancer.</p></div><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/jeanne-martha-focused-giving3-768x576.jpg"/></figure><div class="text"><p>To learn more about a powerful story of friendship and the fight against cancer, please <a href="https://www.dormienetworkfoundation.org/our-impact/golf-outing-fundraiser-jeanne-martha-fore-a-cure-fund-cancer-research" rel="noopener" target="_blank">click here</a>.</p></div></div><!-- /.layout --></div></div><div class="bg-gray section"><div class="row"><div class="layout"><div class="text"><h3>There are many ways to support the Jeanne & Martha Fore A Cure Fund for Cancer Research:</h3><p><strong>Give online via credit card</strong></p><p>To make a gift online visit here and select the link below and follow the prompts.</p><p><a class="button" href="https://give.myiu.org/crowdfunding/I380015965-CF.html" rel="noopener" target="_blank">Give Now</a> </p><p><strong>Give via check</strong></p><p>Please make your check payable to “IU Foundation/Jeanne & Martha Fore A Cure for Cancer Research” and mail to:<br/> IU Simon Comprehensive Cancer Center<br/> c/o IU Foundation<br/> PO Box 7072<br/> Indianapolis, IN 46207 </p><p><strong>Other gifts</strong></p><p>If you have any questions or would like to give via cash wire, stock transfer, or donor-advised fund, please contact Amber Senseny at 317-278-4510.</p></div></div><!-- /.layout --></div></div><div class="bg-crimson bg-dark section"><div class="row"><div class="layout"><h3 class="section-title">Thank you to our philanthropic partners</h3><div class=" grid thirds"><div class="grid-item"><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/logos/thompson_thrift_real_estate-horizontal-653x154.png"/></figure></div><div class="grid-item"><figure class="media image" itemscope="itemscope" itemtype="http://schema.org/ImageObject"><img alt="" src="../../images/logos/dormie-network-foundation-logo.webp"/></figure></div><div class="grid-item"><div class="text"><img alt="Allegion, Pioneering Safety" height="124" src="../../images/logos/allegion-logo-768x640.jpg" style="border: 5px solid #fff; border-width: 5px;" width="148"/></div></div></div></div><!-- /.layout --></div></div></div>
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