1974: Distinguished Professor Lawrence Einhorn, M.D., developed and treated the first patient, John Cleland, with cisplatin chemotherapy. With this new regimen, the cure rate of testicular cancer escalated from 10 percent to nearly 95 percent today.

1984: Distinguished Professor John Donohue, M.D., developed a nerve-sparing surgery for urologic cancers, a procedure that has since been proven to preserve reproductive function in men.

1985: Indiana’s first bone marrow transplant at Riley Hospital for Children.

1988: Hal Broxmeyer, Ph.D., developed the use of human umbilical cord blood as a source of stem cells for transplantation. He prepared the cells for the first cord blood transplantation that cured a patient with Fanconi anemia — a precancerous, genetic condition in children.

1993: First positron emission tomography (PET) scanner in Indiana.

1997: First Gamma-Knife facility in Indiana — a state-of-the-art, noninvasive technology that uses radiation as a “scalpel” to arrest the growth of tumors deep inside the brain.

2000: First combined PET/computerized tomography (CT) system in Indiana.

2000: IU faculty are the first to study bevacizumab — an antibody that prevents the growth of blood vessels that supply cancer cells with the nutrients needed to grow — in advanced cancer patients. Bevacizumab is currently approved by the FDA for metastatic colorectal cancer and under investigation for use in other cancers.

2003: IU faculty are the first to use and report positive results with an extracranial stereotactic body radiation therapy for early-stage lung cancer patients who were not considered candidates for surgery because of medical complications.

2003: First 3 Tesla Magnetic Resonance Imaging (3T MRI) scanner in Indiana.

2004: The Center of Excellence for Individualization of Therapy for Breast Cancer was established and funded by a $10 million grant from the U.S. Department of Defense to study methods for individualizing treatment for women with advanced breast cancer.

2007: Susan G. Komen for the Cure awarded $1 million to establish the Komen Tissue Bank at the IU Simon Cancer Center, the world’s first and only healthy breast tissue bank. Anna Maria Storniolo, M.D., is the tissue bank’s executive director.

2008: David Flockhart, M.D., Ph.D., demonstrated that women taking the cancer drug tamoxifen with certain antidepressants double their chances of the disease returning. The FDA altered the tamoxifen label to include this information.