I am an Assistant Research Professor in the Herman B Wells Center for Pediatric Research at Indiana University School of Medicine with extensive expertise in hematopoiesis, epigenetic regulation, and myeloid malignancies. My research focuses on understanding the molecular mechanisms underlying epigenetics and myeloid leukemias that contribute to clonal hematopoiesis and leukemic transformation. This research directly aligns with the proposed project investigating hematopoietic stem and progenitor cells (HSC/Ps) and their role in AML pathogenesis. I have published 36 peer-reviewed articles with over 2,600 citations, demonstrating significant impact in the field of Integrated Stress Response, RNA biology, hematopoiesis and leukemia research. My work has been published in high-impact journals including JCI Insight, Cell Stem Cell, and Molecular Therapy. My unique qualifications: (1) Extensive experience with Tet2-deficient mouse models and characterization of hematopoietic dysregulation; (2) Expertise in polyribosome profiling, translation efficiency analysis, and ribosome biogenesis studies; (3) Deep understanding of PI3Kinase signaling pathways in myeloid malignancies; (4) Proficiency in RNA-seq analysis, flow cytometry, and bioinformatics tools for Next Generation Sequencing data; and (5) Strong track record in studying the interplay between epigenetic factors and oncogenic signaling in AML.
PhD - Indiana University School of Medicine, Indianapolis, IN 2012
