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Trial Summary

Protocol No.PHO-COG-FALLON-AEWS1031
StatusOPEN TO ACCRUAL
Principal InvestigatorPradhan, Kamnesh
ScopeNational
PhasePhase III
Age GroupChildren
TitleA Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma
DescriptionThis randomized phase III trial is studying combination chemotherapy in treating patients with non-metastatic extracranial Ewing sarcoma. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.
Key EligibilityIn order to be eligible to take part in this trial, patients must meet the following criteria:

  • Be 50 years of age or younger
  • Newly diagnosed extracranial, non-metastatic Ewing sarcoma or primitive neuroectodermal tumors of bone or soft tissue
  • No evidence of metastatic disease
  • No tumors arising in the intra-dural soft tissue
For a full list of participation criteria, please visit clinicaltrials.gov.
Applicable Disease SitesBone Cancer
Participating InstitutionsIU Health North Hospital
    Indiana University (IU)
    • IU Health North (For use by Cancer Center CTO only)
    • Indiana University Hospital / IU Simon Cancer Center
    • Riley Hospital for Children
    Treatment TypeTreatment
    ContactMelissa Lee, Phone: +1 317-944-4281
    Pager: 312-1228
    Email: mellee@iu.edu