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Trial Summary

Protocol No.PCYC-1140-IM
Principal InvestigatorAbu Zaid, Mohammad
PhasePhase III
Age GroupAdult
TitleA Randomized, Double-Blind Phase 3 Study of Ibrutinib in Combination With Corticosteroids versus Placebo in Combination With Corticosteroids in Subjects with New Onset Chronic Graft Versus Host Disease (cGVHD)
DescriptionTo evaluate the safety and efficacy of ibrutinib in combination with prednisone in subjects with newly diagnosed moderate to severe cGVHD.
Key EligibilityIn order to be eligible to take part in this trial, patients must meet the following criteria:

  • 12 years or older
  • New onset moderate or severe cGVHD
For a full list of participation criteria, please visit
Applicable Disease SitesMyeloid and Monocytic Leukemia
Other Hematopoietic
Participating InstitutionsIndiana University (IU)
  • Indiana University Hospital / IU Simon Cancer Center
Treatment TypeTreatment
ContactPhone: (317) 278-5632