Member Biography


Siyuan Zhang

Siyuan Zhang, M.D., Ph.D.

University of Notre Dame
1234 N. Notre Dame Ave., A130 Harper Hall
South Bend, IN 46617
Phone: (574) 631-4635
Fax: (574) 631-2156

Research Program Membership

Full member

Adjunct Assistant Professor of Biochemistry & Molecular Biology
Department of Biochemistry and Molecular Biology
University of Notre Dame

My laboratory is focused on what’s the regulatory role of tumor micronenvironment on development of drug resistance and metastasis. Base on our pre-clinical findings, we also conduct pre-clinical testing of novel combinatorial therapies to overcome drug resistance and prevent tumor metastasis. I received MD degree and Ph.D in cancer biology and molecular cancer therapeutics. My research training as a postdoc fellow at MD Anderson Cancer Center was focused on breast cancer drug resistance and metastasis, particular HER2+ breast cancer. I have special expertise in studying Src signaling and pre-clinical testing different novel combinatorial therapeutics. I also participated the DoD Center of Excellence project on studying breast cancer brain metastasis. Through this highly collaborative project, I have mastered the in vivo models for drug resistance, metastasis and unique techniques in mentoring blood-brain-barrier using animal models.

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Post-doctoral Fellowship - UT MD Anderson Cancer Center, Houston, TX 2011

Ph.D. - National University of Singapore, Singapore 2005

M.D. - Peking University, Beijing, P.R. China 1998