Reginald Hill, Ph.D.
A103 Harper Hall
1234 N. Notre Dame Avenue
South Bend, IN 46617
Phone: (310) 210-7952
Research Program Membership
Archibald Assistant Professor of Cancer Biology
University of Notre Dame
My research interests are investigating the molecular mechanisms through which the microenvironment promotes tumor initiation, progression and therapeutic resistance. The disease in which I've chosen to study these areas is pancreatic ductal adenocarcinoma (PDAC). PDAC is the 4th leading cause of cancer-related deaths in the United States, with a 5-year survival rate of less than 4%. A hallmark of PDAC is a prominent desmoplastic reaction, whereby the microenvironment surrounding the tumor expands due to infiltration of fibroblasts, pancreatic stellate cells, immune cell populations, and endothelial cells. This dense stromal layer can account for up to 90% of the tumor bulk and is believed to serve as a physical impediment to effective pharmacological treatment and to play an important role in the aggressive nature of the disease. Thus, this disease is greatly suited for investigating how the microenvironment aids cancer progression. My proposed work builds on my strengths elucidating both cell-intrinsic and cell-extrinsic factors driving tumorigenesis, and is designed to acquire in depth understanding of the molecular mechanism through which the microenvironment contributes to pancreatic cancer initiation and therapeutic resistance.
Post-doctoral Fellowship - UCLA, Lost Angeles, CA 2005-2012
Ph.D. - University of North Carolina at Chapel Hill, Chapel Hill, NC 1999-2005