Member Biography


Natascia Marino, Ph.D.

980 W. Walnut Street
R3 C238
Indianapolis, IN 46202

Phone: (317) 274-3340

Research Program Membership

Associate member

Assistant Research Professor
Department of Medicine
Division of Hematology/Oncology
IU School of Medicine

Fundamental insights into prevention of breast cancer need a better understanding of the genetics and biology of the normal mammary gland. While substantial information is available about the molecular alterations charactering breast cancer, current understanding of events that initiate or predispose to breast cancer is limited. Now we can improve our knowledge of cancer initiation thanks to the Susan G. Komen Tissue Bank at the IU Simon Cancer Center (KTB) and its unparalleled collection of normal breast tissues. In the present study I plan to evaluate the gene expression profile of two groups of tissue samples: 1) histologically normal breast tissues donated by women who developed breast cancer after normal tissue donation (special normal); 2) normal breast tissue from women with low risk for breast cancer (heathy controls). Using next-generation RNA-sequencing technology and comparing the gene expression profiles of these two groups, I will identify genes important in the first steps of breast cancer formation. Moreover, histological and immunohistological analysis of the specimens will help us to identify changes in the microenvironment, or the area of tissue around the malignant cells. Through this study, I expect to identify abnormalities in histologically normal breast that may elucidate the early step of breast cancer development and identify new markers of cancer susceptibility.

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More Publications »

Ph.D. - Ferrara University, Ferrara, Italy 2007