Lawrence Quilliam, Ph.D.
635 Barnhill Drive
Indianapolis, IN 46202
Phone: (317) 274-8550
Research Program Membership
Department of Biochemistry and Molecular Biology
IU School of Medicine
Delineating signal transduction pathways induced by growth-stimulatory factors, and in determining the mechanisms by which these pathways are aberrantly activated during the course of malignant transformation. Current specific focus is on Lkb1/STK11 regulation of the Hippo pathway. This pathway increases tumor cell growth and proliferation and growth, is independent of LKb1's regulation of AMPK mTOR, is mediated via cell polarity but not the canonical Hippo pathawy and is activated during EMT. We are also interested in the regulation of autophagy, particularly following ER (endoplasmic reticulum) stress. Inhibition of autophagy can prevent cells adapting to stresses such as chemotherapy. This is being studied both in tuberous sclerosis (TSC) and pancreatic cancer (PDAC). In PDAC we focus on events induced by Ral GTPases downstream of KRAS that is mutated in the majority of tumors.
Post-doctoral Fellowship - The Burnham Institute, La Jolla, CA 1991-1992
Post-doctoral Fellowship - The Scripps Research Institute, La Jolla, CA 1988-1991
Post-doctoral Fellowship - University of California-San Diego, La Jolla, CA 1986-1988
Ph.D. - University of Sheffield, U.K. 1983-1986