Member Biography


John Turchi

John Turchi, Ph.D.

980 W. Walnut St.
R3 C562
Indianapolis, IN 46202

Phone: (317) 278-1996

Research Program Membership

Full member

Tom and Julie Wood Family Foundation Professor of Lung Cancer Research
IU School of Medicine

Professor
Department of Medicine
Division of Hematology/Oncology
IU School of Medicine

Professor
Department of Biochemistry and Molecular Biology
IU School of Medicine

Associate Director for Research
Department of Medicine
Division of Hematology/Oncology
IU School of Medicine

Co-leader, Experimental and Developmental Therapeutics Program
IU Simon Cancer Center

Our research is focused on determining the molecular mechanism by which cisplatin imparts its efficacy. We are involved in the identification and development of agents that target specific proteins involved in cisplatin metabolism with the goal of enhancing cisplatin activity in tumors and cancer types that typically do not respond well to cisplatin. We are also involved in research geared towards understanding the interaction of cisplatin and ionizing radiation and how this treatment regimen influences DNA repair pathways. The goal of this research is to enhance the radiosensitization activity of cisplatin. Our final research goal addresses the identification of markers which are measures of chemotherapeutic responsiveness. In this project we employ proteomic analysis in a cisplatin resistant ovarian cancer model.

More information can be found on Dr. Turchi's DNA Repair Lab Web Site.

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Post-doctoral Fellowship - University of Rochester, Rochester, NY 1990-1993

Ph.D. - University of Missouri, Columbia, MO 1985-1990