Member Biography


Claire E. Walczak

Claire Walczak, Ph.D.

915 E. 3rd St.
Myers Hall 262
Bloomington, IN 47405

Phone: (812) 855-5919

Research Program Membership

Full member

Professor
Department of Biochemistry and Molecular Biology
Indiana University at Bloomington

Executive Director, IUB-Light Microscopy Imaging Center

The major goal of mitosis is to distribute the genetic material accurately between the two daughter cells. Defects in meiosis or mitosis lead to aneuploidy, which is a significant cause of birth defects and is a hallmark of tumorigenesis. Despite the cytological description of the mitotic spindle over 100 years ago, we still do not understand how it is assembled or how its activities are spatially and temporally coordinated to facilitate proper segregation of the genetic material. Our lab is interested in the molecular mechanisms that control assembly of the spindle and how the spindle ensures accurate chromosome segregation. Drugs that target the cell division machinery are powerful agents used to treat a number of cancers, and we are working to identify new targets that can be used alone or in combination to develop stronger anti-proliferative agents.

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Post-doctoral Fellowship - University of California, San Francisco, CA 1993-1998

Ph.D. - University of Wisconsin, Madison, WI 1993