Andrea Bonetto, Ph.D.
980 W. Walnut St.
Indianapolis, IN 46202
Phone: (317) 278-8030
Research Program Membership
Assistant Research Professor
Department of Surgery
Division of General Surgery
IU School of Medicine
Beginning with my PhD studies, my personal research interest has been the identification of the molecular causes responsible for muscle wasting, such as the ones frequently observed in both muscular dystrophies and cancer cachexia. The research projects I have been involved in were dealing with the investigation of signaling pathways, whose modulations lead to protein catabolism and muscle depletion/degeneration in either the lack of dystrophin or in the occurrence of a tumor. In particular, during my PhD training I have studied the IGF-1 and Myostatin signaling pathways in both experimental and clinical studies. The role of the IL-6/JAK/STAT3 pathway in cachexia has been the subject of my postdoctoral training. My work was essential to confirm STAT3 as a key transcription factor necessary and sufficient for muscle atrophy to occur. As Assistant Research Professor in the Department of Surgery at Indiana University in Indianapolis I am developing new experimental models of cancer cachexia (colorectal, ovarian and pancreatic cancer) and investigating novel mediators of muscle wasting in both in vitro and in vivo experimental conditions, as well as in the clinical settings. There is a general lack of well-characterized experimental models of cancer cachexia and the ones that are currently in use are rudimentarily phenotyped. Indeed, with few exceptions, cytokine and gene expression information is not available for these models. Our efforts in developing new models of cancer cachexia (in particular associated with colorectal metastatic cancer) will significantly increase the knowledge in the field and will contribute to identify new mediators that will be targeted to cure this complicated syndrome. Recently, I also started to study the effects of chemotherapy on muscle homeostasis and function by taking advantage of both in vitro and in vivo experimental models. These studies, along with the establishment of strategies aimed at improving muscle mass, will become the basis of further work in order to create therapies to target cachexia and reduce chemotherapy side effects, thus prolonging quality of life and survival in cancer patients.
Post-doctoral Fellowship - Thomas Jefferson University, Philadelphia, PA 2011-2013
Post-doctoral Fellowship - University of Miami Miller School of Medicine, Miami, FL 2010-2011
Post-doctoral Fellowship - University of Genova, Genova, Italy 2009-2010
Ph.D. - University of Torino, Torino, Italy 2004-2008