Clinical Pharmacology Analytical Core
Access to high-end instrument for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC. The core has three of these instruments (HPLC-MS/MS; API 4000, Thermo Quantum Ultra, and API 3200) for drug quantification.
Compounds that have been quantified by CPAC include anticancer agents such as:
- paclitaxel and metabolites
- vincristine and metabolite
- mitomycin C
Other compounds that have been quantified by CPAC include:
- midazolam and metabolites
- norgestimate and metabolites
Additionally, CPAC now offers assessments of binding of drugs to plasma proteins. List of publically known drugs with methods already developed (coming soon).