Shared Facilities

Clinical Pharmacology Analytical Core


cpac flow scheme

Access to high-end instrument for quantification of drugs and metabolites is an invaluable resource for all cancer investigators in the IUSCC.  The core has three of these instruments (HPLC-MS/MS; API 4000, Thermo Quantum Ultra, and API 3200) for drug quantification.

Compounds that have been quantified by CPAC include anticancer agents such as:

Anticancer Agents
  • 5-azacytidine
  • carboplatin
  • decitabine
  • docetaxel
  • erlotinib
  • etoposide
  • paclitaxel and metabolites
  • teniposide
  • temozolomide
  • vincristine and metabolite
  • vinorelbine
  • gemcitabine
  • etoposide
  • gemcitabine
  • medroxyprogesterone
  • mitomycin C
  • oxaliplatin

Other compounds that have been quantified by CPAC include:

Other Compounds
  • aprepitant
  • clarithromycin
  • granisetron
  • midazolam and metabolites
  • norethindrone
  • norgestimate and metabolites
  • ondansetron
  • triazolam
  • temazepam

Additionally, CPAC now offers assessments of binding of drugs to plasma proteins. List of publically known drugs with methods already developed (coming soon).