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Cisplatin

May cause:

• Hearing loss (Ototoxicity)
• Kidney (Renal) impairment
• Second cancers (Secondary malignancy)
• Abnormal concentrations of lipids (fats) or lipoproteins (fat-protien complexes) in the blood (Dyslipidemia)
• Inadequate functioning of the testes or ovaries (Hypogonadism)

High-dose Methotrexate

May cause:

• Osteopenia, osteoporosis (A condition of bone in which decreased calcification, decreased density, or reduced mass occurs)
• Renal and liver impairment

Doxorubicin

(usually in the range of 450-600 mg/m2, given with cardioprotectant dexrazoxane) May cause:

• Cardiotoxicity (heart complications)
• Secondary malignancy

Depending on the protocol, some osteosarcoma patients also received the following drugs:

Ifosphamide

(usually in the range of 27-60 mg/m2) May cause:

• Secondary malignancy
• Bladder dysfunction, malignancy
• Renal impairment
• Hypogonadism

Etoposide

May cause:

• Secondary malignancy