Potential Preceptors, Departmental Affiliation & Research
Department of Biochemistry and Molecular Biology
- Irena Petrache, M.D.: Our laboratory investigates the pathogenesis of and repair strategies for the lung injury that occurs in emphysema (COPD). Primarily caused by cigarette smoking, COPD is now the 3rd cause of mortality in the US.
- Lawrence Quilliam, Ph.D.: Signaling via Ras, protein kinases and SH2/SH3 adaptor molecules in cancer.
- Clark D. Wells, Ph.D.: to understand how de-differentiation of mammary epithelial cells during breast cancer initiation and progression is coordinated with the loss of growth control.
- Zhong-Yin Zhang, Ph.D.: Chemical biology, signaling mediated by tyrosine dephosphorylation, targeting protein tyrosine phosphatases for the treatment of cancer.
Department of Dermatology
- Elliot Androphy, M.D.: Mechanism of human papillomavirus–induced malignancies. Development of novel antiviral drugs. Mechanism of p53 tumor suppression.
- Jeffery Travers, M.D., Ph.D.: Characterization of the role of inflammatory lipid mediators in cutaneous inflammation, in particular oxidized glycerophosphocholines with Platelet-activating Factor activity produced in response to pro-oxidative stressors
Department of Medical and Molecular Genetics
Department of Medicine
Department of Microbiology and Immunology
- Janice S. Blum, Ph.D.: Immune regulation, autoimmunity, biodefense, HLA, tumor and viral immunity, vaccines.
- Hal E. Broxmeyer, Ph.D.: Regulation of the self-renewal, survival, proliferation, differentiation and migration of hematopoietic, embryonic, and induced pluripotent stem cells, and hematopoietic progenitor cells, cytokine-cell interactions, intracellular signaling, in-vivo preclinical and clinical assessment, modulation by gene transfer/gene therapy.
- Randy R. Brutkiewicz, Ph.D.: Inhibition of anti-tumor immunity by invariant natural killer T cells and manipulation of these events through gene transfer.
- Mark H. Kaplan, Ph.D.: Stat4 immunobiology, modulation of immune cell reactivity and function by transcription factors such as Stat 3, 4 and 6.
Department of Pediatrics
- Rebecca Chan, M.D., Ph.D.: The functional and biochemical role of several of the observed Shp-2 molecules in murine hematopoietic progenitor cell growth and cytokine response.
- D. Wade Clapp, M.D.: Biochemical and phenotypic effects of heterozygous inactivation of NF1, regulation of hematopoiesis and mast cell production, neurofibromatosis/NF1, gene transfer with retroviral, lentiviral and foamy viral vectors.
- Reuben Kapur, Ph.D.: Molecular genetics of normal and leukemic stem/progenitor cells.
- Mark R. Kelley, Ph.D.: Molecular and cellular biology and biochemistry of eukaryotic DNA base excision repair (BER) genes for basic science and translational applications to treat cancer and small molecule inhibitors of targeted DNA repair genes for anti-angiogenesis and tumor microenvironment therapies.
- Karen Pollok, Ph.D.: Modulation of DNA repair activity in hematopoietic stem and progenitor cells (HSPC) with a focus on in vivo models to study protection of HSC from chemotherapy.
- Mervin C. Yoder, M.D.: Cellular and molecular approaches are combined to elucidate the role of endothelial cells and endothelial colony forming cells in regulating the proliferation and differentiation of hematopoietic stem cells throughout murine ontogeny.
Department of Pharmacology and Toxicology
- Jian-Ting Zhang, Ph.D.: Drug resistance in chemotherapy, signal transduction, translational control and cancer.
Department of Surgery
Department of urology